The host response to allogeneic and xenogeneic biological scaffold materials
Article first published online: 18 FEB 2014
Copyright © 2014 John Wiley & Sons, Ltd.
Journal of Tissue Engineering and Regenerative Medicine
Volume 9, Issue 5, pages 504–511, May 2015
How to Cite
2015), The host response to allogeneic and xenogeneic biological scaffold materials. J Tissue Eng Regen Med, 9, 504–511. doi: 10.1002/term.1874., and (
- Issue published online: 23 APR 2015
- Article first published online: 18 FEB 2014
- Manuscript Accepted: 7 JAN 2014
- Manuscript Revised: 9 SEP 2013
- Manuscript Received: 3 JUN 2013
- host response;
- biological scaffolds;
- extracellular matrix (ECM);
The clinical use of biological scaffold materials has become commonplace. Such scaffolds are composed of extracellular matrix (ECM), or components of ECM, derived from allogeneic or xenogeneic tissues. Such scaffold materials vary widely in their source tissue, processing methods and sterilization methods. The success or failure of an ECM scaffold for a given application is dependent on the host response following implantation; a response that is largely mediated by the innate immune system and which is influenced by a numerous factors, including the processing methods used in the preparation of biological scaffolds. The present paper reviews various aspects of the host response to biological scaffolds and factors that affect this response. In addition, some of the logistical, regulatory and reconstructive implications associated with the use of biological scaffolds are discussed. Copyright © 2014 John Wiley & Sons, Ltd.