Review Article

Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts)

  1. P. C. Bessa1,2,3,*,
  2. M. Casal3,
  3. R. L. Reis1,2

Article first published online: 22 FEB 2008

DOI: 10.1002/term.63

Issue

Journal of Tissue Engineering and Regenerative Medicine

Journal of Tissue Engineering and Regenerative Medicine

Volume 2, Issue 1, pages 1–13, January 2008

Additional Information

How to Cite

Bessa, P. C., Casal, M. and Reis, R. L. (2008), Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts). J Tissue Eng Regen Med, 2: 1–13. doi: 10.1002/term.63

Author Information

  1. 1

    3Bs Research Group, Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal

  2. 2

    Institute for Biotechnology and Bioengineering (IBB), PT Government Associated Laboratory, 4710-057 Braga, Portugal

  3. 3

    Molecular and Environmental Biology Centre (CBMA)/Biology Department, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal

*3Bs Research Group, Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.

Publication History

  1. Issue published online: 25 MAR 2008
  2. Article first published online: 22 FEB 2008
  3. Manuscript Accepted: 2 JAN 2008
  4. Manuscript Received: 26 NOV 2007

Funded by

  • Fundação para a Ciência e Tecnologia, Portugal. Grant Number: SFRH/BD/17049/2004
  • European NoE EXPERTISSUES. Grant Number: NMP3-CT-2004-500283

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (289K)

Keywords:

  • bone morphogenetic proteins;
  • bone morphogenetic protein receptor;
  • Smad signalling;
  • BMP signalling;
  • recombinant BMP;
  • tissue engineering

Abstract

Discovered in 1965, bone morphogenetic proteins (BMPs) are a group of cytokines from the transforming growth factor-β (TGFβ) superfamily with significant roles in bone and cartilage formation. BMPs are used as powerful osteoinductive components of diverse tissue-engineering products for the healing of bone. Several BMPs with different physiological roles have been identified in humans. The purpose of this review is to cover the biological function of the main members of BMP family, the latest research on BMPs signalling pathways and advances in the production of recombinant BMPs for tissue engineering purposes. Copyright © 2008 John Wiley & Sons, Ltd.

Get PDF (289K)