Inorganic arsenic induces necrosis of human CD34-positive haematopoietic stem cells
Version of Record online: 23 JAN 2008
Copyright © 2008 Wiley Periodicals, Inc.
Volume 23, Issue 2, pages 263–268, April 2008
How to Cite
Vernhet, L., Morzadec, C., van Grevenynghe, J., Bareau, B., Corolleur, M., Fest, T. and Fardel, O. (2008), Inorganic arsenic induces necrosis of human CD34-positive haematopoietic stem cells. Environ. Toxicol., 23: 263–268. doi: 10.1002/tox.20334
- Issue online: 11 MAR 2008
- Version of Record online: 23 JAN 2008
- Manuscript Accepted: 1 SEP 2007
- Manuscript Revised: 21 AUG 2007
- Manuscript Received: 22 JUN 2007
- Association pour la Recherche sur le Cancer
- Ligue Contre le Cancer (Comité d'Ille-et-Vilaine)
- human progenitors;
- CD34-positive cells
Inorganic arsenic is a major environmental contaminant known to exert immunosuppressive effects. In this study, we report toxicity of As2O3, a trivalent inorganic form, toward isolated human hematopoietic CD34+ progenitor cells. Our results demonstrate that low concentrations of As2O3 (0.1–5 μM) inhibit in vitro proliferation of CD34+ cells and their differentiation into various hematological cell lineages. These effects were associated with the induction of a necrotic process independent of caspases and likely related to mitochondrial damage. We conclude that As2O3 can impair in vitro human hematopoiesis by decreasing survival of CD34+ progenitor cells. © 2008 Wiley Periodicals, Inc. Environ Toxicol, 2008.