In vitro cytotoxicities of ionic liquids: Effect of cation rings, functional groups, and anions
Article first published online: 29 SEP 2008
Copyright © 2008 Wiley Periodicals, Inc.
Volume 24, Issue 4, pages 388–395, August 2009
How to Cite
Kumar, R. A., Papaïconomou, N., Lee, J.-M., Salminen, J., Clark, D. S. and Prausnitz, J. M. (2009), In vitro cytotoxicities of ionic liquids: Effect of cation rings, functional groups, and anions. Environ. Toxicol., 24: 388–395. doi: 10.1002/tox.20443
- Issue published online: 1 JUL 2009
- Article first published online: 29 SEP 2008
- Manuscript Accepted: 9 AUG 2008
- Manuscript Revised: 25 JUL 2008
- Manuscript Received: 19 MAR 2008
- Office for Basic Sciences of the U.S. Department of Energy
- ionic liquids;
- task-specific ionic liquids
In vitro cytotoxicities were measured for ionic liquids (ILs) containing various cations and anions using the MCF7 human breast cancer cell line. We measured the cytotoxicities of ionic liquids containing the cations pyridinium, pyrrolidinium, piperidinium, or imidazolium with various alkyl chain lengths, and the anions bromide, bis(trifluoromethanesulfone)imide (Tf2N), trifluoromethylsulfonate (TfO), or nonafluoromethylsulfonate (NfO). Three new hydrophobic, task-specific ionic liquids (TSILs), namely, [MBCNPip]+[Tf2N]−, [MPS2Pip]+[Tf2N]−, and [MPS2Pyrro]+[Tf2N]− designed for metal-ion extraction were also evaluated. IC50 values of the ionic liquids toward the MCF7 cells ranged from 8 μM to 44 mM. The toxicity depended significantly on the nature of the cations and anions, especially when the cations contained a long side chain. TSILs studied in this work were less toxic than the classical ILs. © 2008 Wiley Periodicals, Inc. Environ Toxicol, 2009.