Arsenic methylation capacity and its correlation with skin lesions induced by contaminated drinking water consumption in residents of chronic arsenicosis area
Article first published online: 18 SEP 2009
Copyright © 2009 Wiley Periodicals, Inc.
Volume 26, Issue 2, pages 118–123, April 2011
How to Cite
Li, X., Li, B., Xu, Y., Wang, Y., Jin, Y., Itoh, T., Yoshida, T. and Sun, G. (2011), Arsenic methylation capacity and its correlation with skin lesions induced by contaminated drinking water consumption in residents of chronic arsenicosis area. Environ. Toxicol., 26: 118–123. doi: 10.1002/tox.20535
- Issue published online: 18 SEP 2009
- Article first published online: 18 SEP 2009
- Manuscript Accepted: 24 JUL 2009
- Manuscript Revised: 22 JUL 2009
- Manuscript Received: 2 APR 2009
- National Natural Science Foundation of China (NSFC). Grant Numbers: 30400362, 30530640, 30600510
- chronic arsenicosis;
- skin lesions;
- drinking water
Chronic exposure to excess level of arsenic through contaminated drinking water is associated with many injuries, among which skin lesions are the most prominent. In this study, we measured the concentrations of inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) in the blood of the residents of arsenicosis area, who demonstrated different skin lesion grade from mild, moderate to advanced. We evaluated the individual methylation capacity by two indices of the first and secondary methylation ratio (FMR and SMR). We found that SMR of moderate and advanced groups were markedly lower than that of mild group. Significant negative correlation was found between SMR of all the subjects and the grade of skin lesion, with Spearman's correlation coefficient of −0.429 (P = 0.016). Moreover, blood MMA proportion of moderate and advanced groups was found to be significantly higher than that of the mild group. These results suggest that low secondary arsenic methylation capacity and high MMA proportion are associated with the severity of arsenic-related skin lesions. Our findings evaluated by blood speciation is consistent with that evaluated by the generally accepted urinary arsenic speciation in the relationship between arsenic methylation capacity and arsenic-related lesions. © 2009 Wiley Periodicals, Inc. Environ Toxicol 26: 118–123, 2011.