These authors contributed equally to this work.
Quercetin attenuates lambda cyhalothrin-induced reproductive toxicity in male rats
Article first published online: 2 SEP 2011
Copyright © 2011 Wiley Periodicals, Inc.
Volume 28, Issue 12, pages 673–680, December 2013
How to Cite
Ben Abdallah, F., Fetoui, H., Zribi, N., Fakhfakh, F. and Keskes, L. (2013), Quercetin attenuates lambda cyhalothrin-induced reproductive toxicity in male rats. Environ. Toxicol., 28: 673–680. doi: 10.1002/tox.20762
- Issue published online: 5 NOV 2013
- Article first published online: 2 SEP 2011
- Manuscript Accepted: 10 JUL 2011
- Manuscript Revised: 30 JUN 2011
- Manuscript Received: 14 JAN 2011
- reproductive system;
- antioxidants enzyme activities;
- histopathology of the testis
The aim of this study was to evaluate the possible protective effects of Quercetin (Qe) against oxidative stress induced by λ cyhalothrin (LTC) in reproductive system. Thirty-two male rats were divided into four groups. First group was allocated as the control group. Second group was given a Qe alone while the third group received a LTC alone. Animals in the fourth group were given a Qe with LTC. Caudae epididymis was removed for sperm analysis. Lipid peroxidation (LPO), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and reduced glutathione (GSH) were determined in the testis. Additionally, the different histopathologic changes were observed in the testis of animals. LTC exposure significantly increased the abnormal morphology and LPO. On the contrary, sperm motility, viability and count, levels of GSH, and activities of SOD, CAT, GPx, and GST were significantly decreased compared to controls. Qe with LTC offset the decrease in functional sperm parameters, antioxidants enzymatic activities, and nonenzymatic antioxidant levels when compared with LTC-treated rats. Furthermore, LTC showed irregular seminiferous tubules containing only Sertoli cells and Qe with LTC caused regular seminiferous tubules showing spermatogenesis at level of spermatocytes. We conclude that LTC-induced oxidative stress and functional sperm parameters in male rats, and dietary of Qe attenuates the reproductive toxicity of LTC to restore the antioxidant system and sperm parameters in male rats. © 2011 Wiley Periodicals, Inc. Environ Toxicol 28: 673–680, 2013.