Comparison of speciated arsenic levels in the liver and brain of mice between arsenate and arsenite exposure at the early life
Article first published online: 21 AUG 2012
Copyright © 2012 Wiley Periodicals, Inc.
How to Cite
Lu, C., Zhao, F., Sun, D., Zhong, Y., Yu, X., Li, G., Lv, X., Sun, G. and Jin, Y. (2012), Comparison of speciated arsenic levels in the liver and brain of mice between arsenate and arsenite exposure at the early life. Environ. Toxicol.. doi: 10.1002/tox.21808
- Article first published online: 21 AUG 2012
- Manuscript Accepted: 25 JUL 2012
- Manuscript Revised: 24 JUL 2012
- Manuscript Received: 21 MAR 2012
- National Natural Scientific Foundation of China. Grant Numbers: 30571590, 30972441
- arsenic species;
- early life exposure;
The aim of this study was to compare the risk from exposure to arsenate (iAsV) or arsenite (iAsIII) at the early life. Mother mice were exposed to equimolar dose of iAsV and iAsIII via drinking water during gestation and lactation. Their offspring continually drank the same water after weaning. Levels of speciated arsenic in both liver and brain were analyzed by hydride generation of volatile arsines and atomic absorption spectrophotometry (HG-AAS). In the liver, inorganic arsenic (iAs) levels significantly increased from postnatal day (PND) 15, and those on PND 35 were significantly higher than on PND 15 and 21 in iAsIII exposed mice, but iAs levels did not significantly differ until PND 35 in iAsV exposed mice; Furthermore, all speciated arsenic levels on PND 35 and dimethylarsinic acid (DMA) levels on PND 1 were significantly higher in iAsIII exposed mice than those in iAsV exposed mice. In the brain, iAs levels increased significantly on PND 21, but those declined sharply on PND 35 in either iAsIII or iAsV exposed mice, however the mean difference between the two exposure groups was not significant; whereas DMA levels in iAsIII exposed mice were significantly higher than those in iAsV exposed mice on both PND 1 and 35. In conclusion, findings from this study suggested that iAsIII was preferentially accumulated into liver, and expected to result in more efficient methylation capacity than iAsV; either iAsV or iAsIII might be accumulated in the brain readily, when immature blood brain barrier can not limit it into brain. Hence, exposure to either iAsV or iAsIII at the early life may increase the risk of iAs exposure in the brain. © 2012 Wiley Periodicals, Inc. Environ Toxicol, 2012.