Genotoxic and oxidative responses in coelomocytes of Eisenia fetida and Hediste diversicolor exposed to lipid-coated CdSe/ZnS quantum dots and CdCl2

Authors

  • Gladys Saez,

    1. Laboratoire de Mutagenèse Environnementale, Institut Méditerranéen de Biodiversité et d'Ecologie, Faculté de Pharmacie, Aix-Marseille Université, Marseille, Cedex 05, France
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  • Mélanie Aye,

    1. Laboratoire de Mutagenèse Environnementale, Institut Méditerranéen de Biodiversité et d'Ecologie, Faculté de Pharmacie, Aix-Marseille Université, Marseille, Cedex 05, France
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  • Michel De Meo,

    1. Laboratoire de Mutagenèse Environnementale, Institut Méditerranéen de Biodiversité et d'Ecologie, Faculté de Pharmacie, Aix-Marseille Université, Marseille, Cedex 05, France
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  • Ahissan Aimé,

    1. INSERM, U869, ARNA Laboratory, Bordeaux, France
    2. University of Bordeaux, ARNA Laboratory, Bordeaux, France
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  • Isabelle Bestel,

    1. INSERM, U869, ARNA Laboratory, Bordeaux, France
    2. University of Bordeaux, ARNA Laboratory, Bordeaux, France
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  • Philippe Barthélémy,

    1. INSERM, U869, ARNA Laboratory, Bordeaux, France
    2. University of Bordeaux, ARNA Laboratory, Bordeaux, France
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  • Carole Di Giorgio

    Corresponding author
    1. Laboratoire de Mutagenèse Environnementale, Institut Méditerranéen de Biodiversité et d'Ecologie, Faculté de Pharmacie, Aix-Marseille Université, Marseille, Cedex 05, France
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ABSTRACT

The emerging of Quantum Dots utilization in industrial or medicinal fields involved a potentially increase of these nanoparticles in environment. In this work, the genotoxic (comet assay) and oxidative effects (SOD activity, TBARS) of functionalized-QDs and cadmium chloride were investigated on Hediste diversicolor and Eisenia fetida coelomocytes. Results demonstrated that functionalized-QDs (QDNs) and cadmium chloride induced DNA damages through different mechanisms that depended on the nano- or ionic nature of Cd. The minimal genotoxic concentrations for H. diversicolor (<0.001ng/g for QDNs and CdCl2) were lower than for E. fetida (between 0.01 and 0.1 ng/g for QDNs, and between 0.001 and 0.01 ng/g for CdCl2). These results showed that H. diversicolor was more sensitive than E. fetida. The two contaminants had a low impact on the oxidative stress markers. © 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 918–926, 2015.

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