This article presents general implications for using interactive electronic picture books in the classroom. The suggestions are rooted in research with middle grades readers in a tutoring setting and kindergarten through fourth-grade classroom settings. Specific attention is given toward those features in eBooks that may distract, support, or extend comprehension. The article also addresses ways to familiarize students with multi-touch tablet devices while encouraging students and teachers to transfer print-based reading strategies to this new medium. In addition, the authors provide a framework for considering the relationship between interactive features in eBooks and students’ comprehension while establishing the need for more scaffolding of reading instruction when using ebooks.