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Table S1 Nuchal translucency (NT) thresholds below which the probability of repeat measurements leading to a change in likelihood ratio (LR) is low. The cut-off values are based on the simulated sets of five repeat measurements, using an intraobserver SD of 0.13 mm.

Table S2 Nuchal translucency (NT) thresholds below which the probability of repeat measurements leading to a change in likelihood ratio (LR) is low. The cut-off values are based on the simulated sets of five repeat measurements, using an intraobserver SD of 0.16 mm.

Figure S1 Simulated distribution of maximum nuchal translucency (NT) value for sets of two-five repeat measurements for a given crown-rump length of 50 mm, 70 mm or 80 mm and conditional on the first NT measurement obtained. Likelihood ratios (LR) are also shown corresponding to the NT values.

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