Fetal head biometry following in-utero repair of myelomeningocele
Article first published online: 1 NOV 2004
Copyright © 2004 ISUOG. Published by John Wiley & Sons, Ltd.
Ultrasound in Obstetrics & Gynecology
Volume 24, Issue 6, pages 606–611, November 2004
How to Cite
Danzer, E., Johnson, M. P., Wilson, R. D., Flake, A. W., Hedrick, H. L., Sutton, L. N. and Adzick, N. S. (2004), Fetal head biometry following in-utero repair of myelomeningocele. Ultrasound Obstet Gynecol, 24: 606–611. doi: 10.1002/uog.1780
- Issue published online: 1 NOV 2004
- Article first published online: 1 NOV 2004
- Manuscript Accepted: 29 SEP 2004
- cortical index;
- fetal brain development;
- fetal surgery;
- head circumference;
To evaluate the impact of prenatal myelomeningocele repair on fetal head biometry.
Fifty fetuses underwent open fetal myelomeningocele repair at our institution between January 1998 and July 2002. All had serial head circumference (HC) and lateral ventricular diameter (VD) measurements taken preoperatively and weekly for 8 weeks after repair. Cortical index (CI) was defined as HC/VD. Measurements were compared with gestational age-matched values from nomograms. One-sample t-test, ANOVA and repeated measures analysis were used to assess HC, VD and CI after fetal repair.
Preoperatively, the HC in fetuses with myelomeningocele was smaller than control values (186.4 vs. 198.8 mm, P = 0.0004). Eight weeks' postoperatively this difference had resolved (293 vs. 301.6 mm, P = 0.76). The mean increase in CI after repair was 20% (P = 0.02) compared with the predicted 51% in normal cases. The average increase in VD was 3.9 mm (38.8%, P < 0.001).
Mid-gestational repair of myelomeningocele alters fetal head growth. Increased CI suggests HC changes are not due to ventriculomegaly alone. Copyright © 2004 ISUOG. Published by John Wiley & Sons, Ltd.