Three-dimensional ultrasound volume calculations of human embryos and young fetuses: a study on the volumetry of compound structures and its reproducibility
Article first published online: 19 MAY 2006
Copyright © 2006 ISUOG. Published by John Wiley & Sons, Ltd.
Ultrasound in Obstetrics & Gynecology
Volume 27, Issue 6, pages 640–646, June 2006
How to Cite
Blaas, H.-G. K., Taipale, P., Torp, H. and Eik-Nes, S. H. (2006), Three-dimensional ultrasound volume calculations of human embryos and young fetuses: a study on the volumetry of compound structures and its reproducibility. Ultrasound Obstet Gynecol, 27: 640–646. doi: 10.1002/uog.2794
- Issue published online: 19 MAY 2006
- Article first published online: 19 MAY 2006
- Manuscript Accepted: 5 OCT 2005
- embryonic/fetal limb volume;
- embryonic volume/weight;
- fetal volume/weight;
- geometry visualization;
- three-dimensional ultrasound;
- volume measurements
To evaluate volumetry with three-dimensional (3D) ultrasonography in the assessment of the size of human embryos and fetuses.
Forty-four healthy embryos/fetuses with crown–rump length (CRL) ranging from 9 mm to 58 mm were studied using a 7.5-MHz annular array transvaginal 3D probe. EchoPAC 3D software was used to calculate the volumes of the head, body and limbs in the same data set by two observers working independently of each other. Regression analysis was used to assess the relationship between estimated volumes and CRL.
The embryonic and fetal volume estimates of both observers ranged from a mean of 93 mm3 at 10 mm CRL to a mean of 11 169 mm3 at 55 mm CRL. The volume of the limbs as a proportion of the mean whole-body volume increased from 4.7% at a CRL of 15 mm to 9.3% at a CRL of 55 mm. Limits of agreement between the observers were calculated to be −0.12 ± 9.2%.
It is possible to reconstruct complex small anatomic structures and calculate the volumes of human embryos and fetuses in vivo by using dedicated 3D ultrasound equipment. The reproducibility of whole-body volume estimates seems to be high. The limbs represent a significant proportion of the size of the embryonic/fetal body. Copyright © 2006 ISUOG. Published by John Wiley & Sons, Ltd.