Dr A. Thomas and Dr T. Fischer contributed equally to this manuscript.
Real-time elastography — an advanced method of ultrasound: first results in 108 patients with breast lesions
Article first published online: 14 AUG 2006
Copyright © 2006 ISUOG. Published by John Wiley & Sons, Ltd.
Ultrasound in Obstetrics & Gynecology
Volume 28, Issue 3, pages 335–340, September 2006
How to Cite
Thomas, A., Fischer, T., Frey, H., Ohlinger, R., Grunwald, S., Blohmer, J.-U., Winzer, K.-J., Weber, S., Kristiansen, G., Ebert, B. and Kümmel, S. (2006), Real-time elastography — an advanced method of ultrasound: first results in 108 patients with breast lesions. Ultrasound Obstet Gynecol, 28: 335–340. doi: 10.1002/uog.2823
- Issue published online: 14 AUG 2006
- Article first published online: 14 AUG 2006
- Manuscript Accepted: 14 MAR 2006
- breast lesion;
- real-time elastography;
To evaluate whether real-time elastography, a new, non-invasive method for the diagnosis of breast cancer, improves the differentiation and characterization of benign and malignant breast lesions.
Real-time elastography was carried out in 108 potential breast tumor patients with cytologically or histologically confirmed focal breast lesions (59 benign, 49 malignant; median age, 53.9 years; range, 16–84 years). Tumor and healthy tissue were differentiated by measurement of elasticity based on the correlation between tissue properties and elasticity modulus. Evaluation was performed using the three-dimensional (3D) finite element method, in which the information is color-coded and superimposed on the B-mode ultrasound image. A second observer evaluated the elastography images, in order to improve the objectivity of the method. The results of B-mode scan and elastography were compared with those of histology and previous sonographic findings. Sensitivities and specificities were calculated, taking histology as the gold standard.
B-mode ultrasound had a sensitivity of 91.8% and a specificity of 78%, compared with sensitivities of 77.6% and 79.6% and specificities of 91.5% and 84.7%, respectively, for the two observers evaluating elastography. Agreement between B-mode ultrasound and elastography was good, yielding a weighted kappa of 0.67.
Our initial clinical results suggest that real-time elastography improves the specificity of breast lesion diagnosis and is a promising new approach for the diagnosis of breast cancer. Elastography provides additional information for differentiating malignant BI-RADS (breast imaging reporting and data system) category IV lesions. Copyright © 2006 ISUOG. Published by John Wiley & Sons, Ltd.