Clinical improvement and shrinkage of uterine fibroids after thermal ablation by magnetic resonance-guided focused ultrasound surgery

Authors

  • J. Rabinovici,

    Corresponding author
    1. Department of Obstetrics and Gynecology, Sheba Medical Center, Ramat Gan, Israel
    2. Department of Radiology, Sheba Medical Center, Ramat Gan, Israel
    • Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Ramat Gan 52560, Israel
    Search for more papers by this author
  • Y. Inbar,

    1. Department of Radiology, Sheba Medical Center, Ramat Gan, Israel
    2. Department of Sackler Medical School, Tel-Aviv University, Tel Aviv, Israel
    Search for more papers by this author
  • A. Revel,

    1. Department of Obstetrics and Gynecology, Hadassa Ein Kerem University Hospital, Israel
    2. Department of Medical School, Hebrew University, Jerusalem, Israel
    Search for more papers by this author
  • Y. Zalel,

    1. Department of Obstetrics and Gynecology, Sheba Medical Center, Ramat Gan, Israel
    2. Department of Radiology, Sheba Medical Center, Ramat Gan, Israel
    Search for more papers by this author
  • J. M. Gomori,

    1. Department of Radiology, Hadassa Ein Kerem University Hospital, Israel
    2. Department of Medical School, Hebrew University, Jerusalem, Israel
    Search for more papers by this author
  • Y. Itzchak,

    1. Department of Radiology, Sheba Medical Center, Ramat Gan, Israel
    2. Department of Sackler Medical School, Tel-Aviv University, Tel Aviv, Israel
    Search for more papers by this author
  • E. Schiff,

    1. Department of Obstetrics and Gynecology, Sheba Medical Center, Ramat Gan, Israel
    Search for more papers by this author
  • S. Yagel

    1. Department of Obstetrics and Gynecology, Hadassa Ein Kerem University Hospital, Israel
    2. Department of Medical School, Hebrew University, Jerusalem, Israel
    Search for more papers by this author

Abstract

Objective

Hysterectomy or myomectomy are the accepted treatments for symptomatic uterine fibroids. Heat ablation of uterine fibroids has been shown to be an effective alternative treatment. The aim of this study was to determine the clinical efficacy of non-invasive thermal ablation by transcutaneous magnetic resonance-guided high-intensity focused ultrasound (MRgFUS) for the treatment of symptomatic uterine fibroids.

Methods

In this prospective study, MRgFUS ablation of uterine fibroids was performed in 35 symptomatic women scheduled for hysterectomy. Clinical symptoms, patient satisfaction and uterine size were determined at 1 month and 6 months after the procedure.

Results

This outpatient procedure was very well tolerated by all women. Sixty-nine percent (24/35) of the treated patients reported either significant or partial improvement in symptoms. Treated fibroids decreased in volume by 12% and 15% at 1 and 6 months, respectively. Minor transient side-effects were observed in two women. Six women underwent hysterectomy during the follow-up period.

Conclusion

This study demonstrates the clinical efficacy of MRgFUS ablation of uterine fibroids. This novel, non-invasive surgical approach may offer an alternative therapy for women with uterine fibroids. Copyright © 2007 ISUOG. Published by John Wiley & Sons, Ltd.

Ancillary