Predictive value of angiogenic factors and uterine artery Doppler for early- versus late-onset pre-eclampsia and intrauterine growth restriction
Article first published online: 3 DEC 2007
Copyright © 2007 ISUOG. Published by John Wiley & Sons, Ltd.
Ultrasound in Obstetrics & Gynecology
Volume 31, Issue 3, pages 303–309, March 2008
How to Cite
Crispi, F., Llurba, E., Domínguez, C., Martín-Gallán, P., Cabero, L. and Gratacós, E. (2008), Predictive value of angiogenic factors and uterine artery Doppler for early- versus late-onset pre-eclampsia and intrauterine growth restriction. Ultrasound Obstet Gynecol, 31: 303–309. doi: 10.1002/uog.5184
- Issue published online: 28 FEB 2008
- Article first published online: 3 DEC 2007
- Manuscript Accepted: 12 JUN 2007
- Supported by grants from the Fondo the Investigación Sanitaria (FIS 01/1397 and 02/0742), Centre Network RCMN (C03/08), and Group Network (G03/054) financed by the Carlos III Institute of Health (Madrid, Spain)
- intrauterine growth restriction;
- placental growth factor;
- soluble fms-like tyrosine kinase 1;
- uterine artery Doppler
To investigate potential differences in the prediction of early- vs. late-onset pre-eclampsia and/or intrauterine growth restriction (PE/IUGR) by second-trimester uterine artery Doppler examination, and measurement of maternal serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt1).
Uterine artery mean pulsatility index (PI) and maternal serum PlGF and sFlt1 levels were measured at 24 weeks of gestation in 76 healthy pregnant women and 38 cases of PE/IUGR, of which 19 were defined as early onset (< 32 weeks).
For a specificity of 95%, the sensitivities of uterine artery mean PI, PlGF and sFlt1 for early-onset PE/IUGR were 47.4%, 84.4% and 36.8%, respectively. When combining uterine artery Doppler with PlGF, the sensitivity for identifying early-onset PE/IUGR was 89.5% with a specificity of 95%. Conversely, the sensitivity for late-onset PE/IUGR was below 11% for all parameters analyzed.
Angiogenic factors and uterine artery Doppler evaluation may be useful second-trimester screening tests for early-onset, but not late-onset, PE/IUGR. Copyright © 2007 ISUOG. Published by John Wiley & Sons, Ltd.