Original Paper

You have full text access to this OnlineOpen article

Maternal and fetal hemodynamic effects induced by nitric oxide donors and plasma volume expansion in pregnancies with gestational hypertension complicated by intrauterine growth restriction with absent end-diastolic flow in the umbilical artery

  1. H. Valensise1,*,
  2. B. Vasapollo1,
  3. G. P. Novelli1,2,
  4. G. Giorgi2,
  5. P. Verallo2,
  6. A. Galante3,
  7. D. Arduini1

Article first published online: 21 DEC 2007

DOI: 10.1002/uog.5234

Issue

Ultrasound in Obstetrics & Gynecology

Ultrasound in Obstetrics & Gynecology

Volume 31, Issue 1, pages 55–64, January 2008

Additional Information

How to Cite

Valensise, H., Vasapollo, B., Novelli, G. P., Giorgi, G., Verallo, P., Galante, A. and Arduini, D. (2008), Maternal and fetal hemodynamic effects induced by nitric oxide donors and plasma volume expansion in pregnancies with gestational hypertension complicated by intrauterine growth restriction with absent end-diastolic flow in the umbilical artery. Ultrasound Obstet Gynecol, 31: 55–64. doi: 10.1002/uog.5234

Author Information

  1. 1

    Department of Obstetrics and Gynecology, Perinatal Medicine, Frascati (Rome), Rome, Italy

  2. 2

    Department of Cardiology, San Sebastiano Martire Hospital, Frascati (Rome), Rome, Italy

  3. 3

    Emergency Department, Tor Vergata University, Frascati (Rome), Rome, Italy

*Università di Roma ‘Tor Vergata’, Dipartimento di Ginecologia ed Ostetricia, Ospedale Fatebenefratelli, Isola Tiberina 39, 00100, Roma, Italy

Publication History

  1. Issue published online: 21 DEC 2007
  2. Article first published online: 21 DEC 2007
  3. Manuscript Accepted: 30 OCT 2007

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (211K)

References

  • 1
    Vasapollo B, Valensise H, Novelli GP, Larciprete G, Di Pierro G, Altomare F, Casalino B, Galante A, Arduini D. Abnormal maternal cardiac function and morphology in pregnancies complicated by intrauterine fetal growth restriction. Ultrasound Obstet Gynecol 2002; 20: 452–457.
    Direct Link:
  • 2
    Nisell H, Lunell NO, Linde B. Maternal hemodynamics and impaired fetal growth in pregnancy-induced hypertension. Obstet Gynecol 1988; 71: 163–166.
  • 3
    Veille GC, Morton MJ, Paul MS. Maternal left ventricular dimension in pregnancies complicated by fetal growth retardation. Obstet Gynecol 1991; 78: 265–269.
  • 4
    Duvekot JJ, Cheriex EC, Pieters FA, Peeters LH. Severely impaired fetal growth is preceded by maternal hemodynamic maladaptation in very early pregnancy. Acta Obstet Gynecol Scand 1995; 74: 693–697.
  • 5
    Duvekot JJ, Cheriex EC, Pieters FA, Menheere PP, SchoutenHJ, Peeters LH. Maternal volume homeostasis in early pregnancy in relation to fetal growth restriction. Obstet Gynecol 1995; 85: 361–367.
  • 6
    Yallampalli C, Garfield RE. Inhibition of nitric oxide synthesis in rats during pregnancy produces signs similar to those of preeclampsia. Am J Obstet Gynecol 1993; 169: 1316–1320.
  • 7
    Molnar M, Suto T, Toth T, Hertelendy F. Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension proteinuria, thrombocytopenia, and intrauterine growth retardation. Am J Obstet Gynecol 1994; 170: 1458–1466.
  • 8
    Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 1993; 329: 2002–2012.
  • 9
    Makino Y, Izumi H, Makino I, Shirakewa K. The effect of nitric oxide on uterine and umbilical artery flow velocity waveform in pre-eclampsia. Eur J Obstet Gynecol Reprod Biol 1997; 73: 139–143.
  • 10
    Cacciatore B, Halmesmaki E, Kaaja R, Teramo K, Ylikorkala O. Effects of transdermal nitroglycerin on impedance to flow in the uterine, umbilical, and fetal middle cerebral arteries in pregnancies complicated by preeclampsia and intrauterine growth retardation. Am J Obstet Gynecol 1998; 179: 140–145.
  • 11
    Lees C, Valensise H, Black R, Harrington K, Byiers S, Romanini C, Campbell S. The efficacy and fetal-maternal cardiovascular effects of transdermal glyceryl trinitrate in the prophylaxis of pre-eclampsia and its complications: a randomized double-blind placebo-controlled trial. Ultrasound Obstet Gynecol 1998; 12: 334–338.
    Direct Link:
  • 12
    Di Iorio R, Marinoni E, Gazzolo D, Letizia C, Di Netta T, Cosmi E. Maternal nitric oxide supplementation increases adrenomedullin concentrations in growth retarded fetuses. Gynecol Endocrinol 2002; 16: 187–192.
  • 13
    Sehgal N, Hitt J. Plasma volume expansion in the treatment of pre-eclampsia. Am J Obstet Gynecol 1980; 138: 165–168.
  • 14
    Belfort M, Uys P, Dommisse J, Davey DA. Haemodynamic changes in gestational proteinuric hypertension: the effects of rapid volume expansion and vasodilator therapy. Br J Obstet Gynaecol 1989; 96: 634–641.
  • 15
    Ganzevoort W, Rep A, Bonsel GJ, Fetter WP, van Sonderen L, De Vries JI, Wolf H. A Randomised controlled trial comparing two temporising management strategies, one with and one without plasma volume expansion, for severe and early onset pre-eclampsia. BJOG 2005; 112: 1358–1368.
    Direct Link:
  • 16
    Parazzini F, Cortinovis I, Bortolus R, Fedele L, Recarli A. Weight at birth by gestational age in Italy. Hum Reprod 1995; 10: 1862–1863.
  • 17
    Hecher K, Campbell S, Doyle P, Harrington K, Nicolaides K. Assessment of fetal compromise by Doppler ultrasound investigation of fetal circulation. Arterial, intracardiac, and venous blood flow velocity studies. Circulation 1995; 91: 129–138.
  • 18
    Baschat AA, Gembruch U, Reiss I, Gortner L, Weiner CP, Harman CR. Relationship between arterial and venous Doppler and perinatal outcome in fetal growth restriction. Ultrasound Obstet Gynecol 2000; 16: 407–413.
    Direct Link:
  • 19
    Hecher K, Snijders R, Campbell S, Nicolaides K. Fetal venous, intracardiac and arterial blood flow measurements in intrauterine growth retardation: relationship with fetal blood gases. Am J Obstet Gynecol 1995; 173: 10–15.
  • 20
    Valensise H, Novelli GP, Vasapollo B, Borzi M, Arduini D, Galante A, Romanici C. Maternal cardiac systolic and diastolic function: relationship with uteroplacental resistances. A Doppler and echocardiographic longitudinal study. Ultrasound Obstet Gynecol 2000; 15: 487–497.
    Direct Link:
  • 21
    Valensise H, Novelli GP, Vasapollo B, Di Ruzza G, RomaniniME, Marchei M, Larciprete G, Manfellotto D, Romanini C, Galante A. Maternal diastolic dysfunction and left ventricular geometry in gestational hypertension. Hypertension 2001; 37: 1209–1215.
  • 22
    Sahn DJ, De Maria A, Kisslo J, Weyman A. The Committee on M-Mode Standardization of The American Society of Echocardiography. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation 1978; 58: 1072–1083.
  • 23
    Poppas A, Shroff SG, Korcarz CE, Hibbard JU, Berger DS, Lindheimer MD, Lang RM. Serial assessment of the cardiovascular system in normal pregnancy. Role of arterial compliance and pulsatile arterial load. Circulation 1997; 95: 2407–2415.
  • 24
    Devereux RB, Casale PN, Kligfield P, Eisenberg RR, Miller D, Campo E, Alonso DR. Performance of primary and derived M-mode echocardiographic measurements for detection of left ventricular hypertrophy in necropsied subjects and in patients with systemic hypertension, mitral regurgitation and dilated cardiomyopathy. Am J Cardiol 1986; 57: 1388–1393.
  • 25
    de Simone G, Daniels SR, Devereux RB, Meyer RA, Roman MJ, de Divitiis O, Alderman MH. Left ventricular mass and body size in normotensive children and adults: assessment of allometric relations and impact of overweight. J Am Coll Cardiol 1992; 20: 1251–1260.
  • 26
    Easterling TR, Watts DH, Schmucker BC, Benedetti TJ. Measurement of cardiac output during pregnancy: validation of Doppler technique and clinical observations in preeclampsia. Obstet Gynecol 1987; 69: 845–850.
  • 27
    Valensise H, Vasapollo B, Novelli GP, Larciprete G, RomaniniME, Arduini D, Galante A, Romanini C. Maternal diastolic function in asyptomatic pregnant women with bilateral notching of the uterine artery waveform at 24 weeks' gestation. Ultrasound Obstet Gynecol 2001; 18: 450–455.
    Direct Link:
  • 28
    Molnar M, Hertelendy F. Nω-nitro-L-arginine, an inhibitor of nitric oxide synthesis, increases blood pressure in rats and reverses the pregnancy-induced refractoriness to vasopressor agents. Am J Obstet Gynecol 1992; 166: 1560–1567.
  • 29
    Umans JG, Lindheimer MD, Barron WM. Pressor effect of endothelium-derived relaxing factor inhibition in conscious virgin and gravid rats. Am J Physiol 1990; 259: F293–F296.
  • 30
    Sladek SM, Magness RR, Conrad KP. Nitric oxide and pregnancy. Am J Physiol 1997; 272: R441–R463.
  • 31
    Duvekot JJ, Cheriex EC, Pieters FAA, Menheere PPCA, PeetersLLH. Early-pregnancy changes in hemodynamics and volume homeostasis are consecutive adjustments triggered by a primary fall in systemic vascular tone. Am J Obstet Gynecol 1993; 169: 1382–1392.
  • 32
    Mesa A, Jessurun C, Hernandez A, Adam K, Brown D, VaughnWK, Wilansky S. Left ventricular diastolic function in normal human pregnancy. Circulation 1999; 99: 511–517.
  • 33
    Curran-Everett D, Morris KG Jr, Moore LG. Regional circulatory contributions to increased systemic vascular conductance of pregnancy. Am J Physiol 1991; 261: H1842–H1847.
  • 34
    Karsdorp VH, van Vugt JM, Dekker GA, van Geijn HP. Reappearance of end-diastolic velocities in the umbilical artery following maternal volume expansion: a preliminary study. Obstet Gynecol 1992; 80: 679–683.
  • 35
    Boito SM, Struijk PC, Pop GA, Visser W, Steegers EA, Wladimiroff JW. The impact of maternal plasma volume expansion and antihypertensive treatment with intravenous dihydralazine on fetal and maternal hemodynamics during pre-eclampsia: a clinical, echo-Doppler and viscometric study. Ultrasound Obstet Gynecol 2004; 23: 327–332.
    Direct Link:
  • 36
    Wijnberger LD, Bilardo CM, Hecher K, Stigter RH, Visser GH. Effect of antenatal glucocorticoid therapy on arterial and venous blood flow velocity waveforms in severely growth-restricted fetuses. Ultrasound Obstet Gynecol 2004; 23: 584–589.
    Direct Link:
  • 37
    Simchen MJ, Alkazaleh F, Adamson SL, Windrim R, Telford J, Beyene J, Kingdom J. The fetal cardiovascular response to antenatal steroids in severe early-onset intrauterine growth restriction. Am J Obstet Gynecol 2004; 190: 296–304.
  • 38
    Barkehall-Thomas A, Thompson M, Baker LS, Edwards A, Wallace EM. Betamethasone associated changes in umbilical artery flow velocity waveforms in multiple pregnancies with umbilical artery absent end diastolic flow. Aust N Z J Obstet Gynaecol 2003; 43: 360–363.
    Direct Link:
  • 39
    Bilardo CM, Wolf H, Stigter RH, Ville Y, Baez E, Visser GH, Hecher K. Relationship between monitoring parameters and perinatal outcome in severe, early intrauterine growth restriction. Ultrasound Obstet Gynecol 2004; 23: 119–125.
    Direct Link:
View Full Article (HTML) Get PDF (211K)