Thick fetal corpus callosum: an ominous sign?
Article first published online: 15 MAY 2009
Copyright © 2009 ISUOG. Published by John Wiley & Sons, Ltd.
Ultrasound in Obstetrics & Gynecology
Volume 34, Issue 1, pages 55–61, July 2009
How to Cite
Lerman-Sagie, T., Ben-Sira, L., Achiron, R., Schreiber, L., Hermann, G., Lev, D., Kidron, D. and Malinger, G. (2009), Thick fetal corpus callosum: an ominous sign?. Ultrasound Obstet Gynecol, 34: 55–61. doi: 10.1002/uog.6356
- Issue published online: 29 JUN 2009
- Article first published online: 15 MAY 2009
- Manuscript Accepted: 28 NOV 2008
- corpus callosum;
- fetal brain;
- prenatal diagnosis;
Anomalies of the corpus callosum are frequently diagnosed during pregnancy, but a thick corpus callosum is a rare finding and its significance is not clear. We aimed to assess the significance of thick fetal corpus callosum by reviewing our experience of such cases.
The records of all fetuses with anomalies of the corpus callosum referred to the prenatal diagnosis units of two university hospitals from 2000 to 2007 were reviewed. Nine fetuses with a thick corpus callosum were identified.
In all cases there were associated abnormalities: macrocephaly, ventriculomegaly, vermian agenesis, abnormal sulcation or encephalocele. Four pregnancies were terminated and in each of these cases the autopsy confirmed dysmorphic features and additional brain abnormalities. Five infants were delivered; two died shortly after birth, one suffers from mental retardation, one had neonatal convulsions and one is developing normally.
A thick fetal corpus callosum is usually associated with other brain anomalies and is part of a neurogenetic syndrome in most cases. Copyright © 2009 ISUOG. Published by John Wiley & Sons, Ltd.