Feasibility of focused ultrasound therapy for recurrent cervicitis with high-risk human papillomavirus infection
Article first published online: 22 OCT 2009
Copyright © 2009 ISUOG. Published by John Wiley & Sons, Ltd.
Ultrasound in Obstetrics & Gynecology
Volume 34, Issue 5, pages 590–594, November 2009
How to Cite
Li, C.-Z., Wang, Z.-B., Yang, X., Tang, Y., Wang, D., Huang, Y. and Fan, X.-F. (2009), Feasibility of focused ultrasound therapy for recurrent cervicitis with high-risk human papillomavirus infection. Ultrasound Obstet Gynecol, 34: 590–594. doi: 10.1002/uog.7357
- Issue published online: 22 OCT 2009
- Article first published online: 22 OCT 2009
- Manuscript Accepted: 22 JUL 2009
- Foundation of Ministry of Education of China. Grant Number: IRT0454
- National Natural Science Foundation of China. Grant Number: 30325027
- focused ultrasound;
- human papillomaviruses;
To investigate the feasibility of focused ultrasound therapy for recurrent cervicitis with high-risk human papillomavirus (HR-HPV) infection.
This was a prospective clinical study, in which 20 patients with HR-HPV-positive recurrent cervicitis were enrolled. Focused ultrasound therapy was performed by one gynecologist. All patients were followed up for 6 months after ultrasound therapy. Telephone interviews, colposcopic examinations and Hybrid Capture II tests were performed to assess the safety and effectiveness of focused ultrasound therapy for HR-HPV-positive cervicitis.
Ultrasound therapy was tolerated well, and no severe complications were observed in any patient. Vaginal discharge was found intermittently in 95% of patients. Without any intervention this disappeared 1 month after ultrasound therapy. Patients' symptoms were relieved significantly by ultrasound therapy, including 88.9% patients who had abundant leukorrhea, 80% who had pelvic pain and 87.5% who had postcoital bleeding. No colposcopic evidence of cervicitis remained postoperatively in 75% of patients, and cytological examination showed that the lesions had disappeared in 80% of patients. Follow-up HPV testing revealed that 75% of patients presented negative HR-HPV infection following treatment.
Focused ultrasound therapy is feasible and effective in the treatment of patients with HR-HPV-positive cervicitis. It may provide a useful non-invasive treatment for recurrent cervicitis with HR-HPV infection. Copyright © 2009 ISUOG. Published by John Wiley & Sons, Ltd.