Multivariable analysis of tests for the diagnosis of intrauterine growth restriction
Article first published online: 19 MAR 2003
Copyright © 2003 ISUOG. Published by John Wiley & Sons, Ltd.
Ultrasound in Obstetrics & Gynecology
Volume 21, Issue 4, pages 370–374, April 2003
How to Cite
Bachmann, L. M., Khan, K. S., Ogah, J. and Owen, P. (2003), Multivariable analysis of tests for the diagnosis of intrauterine growth restriction. Ultrasound Obstet Gynecol, 21: 370–374. doi: 10.1002/uog.77
- Issue published online: 7 APR 2003
- Article first published online: 19 MAR 2003
- Manuscript Accepted: 18 OCT 2002
- intrauterine growth restriction;
- regression analysis
To describe how data from antenatal fetal ultrasound biometry, amniotic fluid index and umbilical artery Doppler can be appropriately combined using multivariable models and to investigate how the addition of these ultrasound parameters influences the ability to predict intrauterine growth restriction (IUGR).
This was a prospective cohort study involving 274 low-risk pregnancies undergoing serial ultrasound examination at predetermined intervals. Standard deviation (Z) scores of the last values for fetal abdominal area (FAA), growth velocity of the FAA, amniotic fluid index (AFI) and umbilical artery Doppler pulsatility index prior to delivery were calculated for 260 fetuses. Customized estimated fetal weight (cEFW) centiles were also calculated using the last EFW before delivery after adjustment for fetal gender, gestational age, birth order and maternal weight, height and ethnic origin. Following delivery the neonatal ponderal index was calculated and centile position obtained. A neonatal ponderal index <25th centile served as the main outcome measure for diagnosis of IUGR. Logistic regression analysis was used to delineate the predictive value of the three fetal growth tests FAA, FAA growth velocity and cEFW and the additional values of AFI and pulsatility index of the umbilical artery.
The areas under the receiver–operating characteristics (ROC) curves (95% confidence interval) for FAA, FAA growth velocity and cEFW alone were 0.819 (0.748–0.891), 0.784 (0.699–0.869) and 0.74 (0.643–0.837), respectively, in the prediction of a neonatal ponderal index <25th centile. The addition of both the AFI and pulsatility index to FAA, FAA growth velocity and cEFW generated small increases in the areas, to 0.831 (0.758–0.904), 0.817 (0.735–0.899) and 0.766 (0.672–0.859), respectively. These improvements in diagnostic prediction were not statistically significant.
The addition of AFI and umbilical artery pulsatility index to the fetal biometry parameters did not significantly increase the ROC areas in the study population. The approach applied in this study is useful in the context of hypothesis generation. Further studies using larger data sets and other predictors should be carried out using the analytical techniques outlined in this paper to determine the contribution of various antenatal tests in the prediction of IUGR. Copyright © 2003 ISUOG. Published by John Wiley & Sons, Ltd.