Prediction of fetal macrosomia: effect of sonographic fetal weight-estimation model and threshold used

Authors

  • N. Melamed,

    Corresponding author
    1. Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tiqva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • Department of Obstetrics and Gynecology, Rabin Medical Center, Beilinson Hospital, Petah Tiqva 49100, Israel
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  • Y. Yogev,

    1. Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tiqva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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  • I. Meizner,

    1. Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tiqva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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  • R. Mashiach,

    1. Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tiqva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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  • J. Pardo,

    1. Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tiqva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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  • A. Ben-Haroush

    1. Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tiqva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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Abstract

Objective

To compare the accuracy of 21 sonographic fetal weight-estimation models and abdominal circumference (AC) as a single measure for the prediction of fetal macrosomia (> 4000 g) using either fixed or optimal model-specific thresholds.

Methods

A total of 4765 sonographic weight estimations performed within 3 days prior to delivery were analyzed. The predictive accuracy of 21 published sonographic fetal weight-estimation models was calculated using three different thresholds: a fixed threshold of 4000 g; a model-specific threshold obtained from the inflexion point of the receiver–operating characteristics (ROC) curve; and a model-specific threshold associated with the highest overall accuracy. Cluster analysis was used to determine whether a certain combination of fetal biometric indices is associated with a higher predictive accuracy than others.

Results

For a fixed threshold of > 4000 g, there was considerable variation among the models in sensitivity (range, 13.6–98.5%) and specificity (range, 63.6–99.8%) for fetal macrosomia. Use of the threshold derived from the inflexion point of the ROC curve decreased the intermodel variation to a minimum (sensitivity, 84.4–91.4%; and specificity, 79.5–86.3%). Even when this optimal model-specific threshold was applied, models based on three to four biometric indices were more accurate than were models based on only two biometric indices or on AC as a single measure (P = 0.03).

Conclusions

Sonographic fetal weight-estimation models based on three to four biometric indices appear to be more accurate than are models based on two indices or on AC as a single measure, for the diagnosis of macrosomia. In these cases, the use of an optimal, model-specific threshold is associated with a higher degree of accuracy than is the uniform use of a fixed threshold of an estimated weight of > 4000 g. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.

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