A review of fetal volumetry: the need for standardization and definitions in measurement methodology
Article first published online: 11 NOV 2011
Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
Ultrasound in Obstetrics & Gynecology
Volume 38, Issue 6, pages 613–619, December 2011
How to Cite
Ioannou, C., Sarris, I., Salomon, L. J. and Papageorghiou, A. T. (2011), A review of fetal volumetry: the need for standardization and definitions in measurement methodology. Ultrasound Obstet Gynecol, 38: 613–619. doi: 10.1002/uog.9074
- Issue published online: 25 NOV 2011
- Article first published online: 11 NOV 2011
- Accepted manuscript online: 14 JUN 2011 06:45AM EST
- Manuscript Accepted: 16 MAY 2011
- 3D ultrasound;
- quality control;
Volume charts of fetal organs and structures vary considerably among studies. This review identified 42 studies reporting normal volumes, namely for fetal brain (n = 3), cerebellum (n = 4), liver (n = 6), femur (n = 2), lungs (n = 15), kidneys (n = 3) and first-trimester embryo (n = 9). The differences among median volumes were expressed both in percentage form and as standard deviation scores. Wide discrepancies in reported normal volumes make it extremely difficult to diagnose pathological organ growth reliably. Given its magnitude, this variation is likely to be due to inconsistencies in volumetric methodology, rather than population differences. Complicating factors include the absence of clearly defined anatomical landmarks for measurement; inadequate assessment and reporting of method repeatability; the inherent difficulty in validating fetal measurements in vivo against a reference standard; and a multitude of mutually incompatible three-dimensional (3D) imaging formats and software measuring tools. An attempt to standardize these factors would improve intra- and inter-researcher agreement concerning reported volumetric measures, would allow generalization of reference data across different populations and different ultrasound systems, and would allow quality assurance in 3D fetal biometry. Failure to ensure a quality control process may hamper the wide use of 3D ultrasound. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.