Ultrasonographic measurement of fetal nasal bone in a low-risk population at 19–22 gestational weeks
Article first published online: 29 DEC 2003
Copyright © 2003 ISUOG. Published by John Wiley & Sons, Ltd.
Ultrasound in Obstetrics & Gynecology
Volume 23, Issue 2, pages 152–153, February 2004
How to Cite
Gámez, F., Ferreiro, P. and Salmeán, J. M. (2004), Ultrasonographic measurement of fetal nasal bone in a low-risk population at 19–22 gestational weeks. Ultrasound Obstet Gynecol, 23: 152–153. doi: 10.1002/uog.929
- Issue published online: 2 FEB 2004
- Article first published online: 29 DEC 2003
- Manuscript Accepted: 12 SEP 2003
- Down syndrome;
- nasal bone measurement;
- second trimester;
- trisomy 21
To determine the potential value of sonographic measurement of fetal nasal bone at 19–22 weeks' gestation in screening for trisomy 21 in a low-risk population.
The fetal nasal bone was measured in a mid-sagittal view in 2035 fetuses at 19–22 weeks' gestation. A reference range was constructed and the measurements in fetuses with trisomy 21 were compared to the normal group.
The fetal profile was successfully examined in 1913/2035 (94%) fetuses. The mean nasal bone length increased linearly with gestation from 6.2 mm at 19 weeks to 6.8 mm at 22 weeks. Nasal bone hypoplasia, defined by absence of the bone or a measurement below the 2.5th centile, was observed in 34/1899 (1.8%) chromosomally normal fetuses (1.8%), in 5/5 fetuses with trisomy 21 and in 0/9 fetuses with other chromosomal defects.
At 19–22 weeks' gestation, nasal bone hypoplasia is observed in a high proportion of trisomy 21 fetuses and in less than 2% of chromosomally normal fetuses. Copyright © 2003 ISUOG. Published by John Wiley & Sons, Ltd.