Salivary gland organogenesis
Article first published online: 17 NOV 2011
Copyright © 2011 Wiley Periodicals, Inc.
Wiley Interdisciplinary Reviews: Developmental Biology
Volume 1, Issue 1, pages 69–82, January/February 2012
How to Cite
Knosp, W. M., Knox, S. M. and Hoffman, M. P. (2012), Salivary gland organogenesis. WIREs Dev Biol, 1: 69–82. doi: 10.1002/wdev.4
- Issue published online: 14 DEC 2011
- Article first published online: 17 NOV 2011
Our understanding of vertebrate salivary gland organogenesis has been largely informed by the study of the developing mouse submandibular gland (SMG), which will be the major focus of this review. The mouse SMG has been historically used as a model system to study epithelial–mesenchymal interactions, growth factor–extracellular matrix (ECM) interactions, and branching morphogenesis. SMG organogenesis involves interactions between a variety of cell types and their stem/progenitor cells, including the epithelial, neuronal, and mesenchymal cells, and their ECM microenvironment, or niche. Here, we will review recent literature that provides conceptual advances in understanding the molecular mechanisms of salivary gland development. We will describe SMG organogenesis, introduce the model systems used to study development, and outline the key signaling pathways and cellular processes involved. We will also review recent research focusing on the identification of stem/progenitor cells in the SMG and how they are directed along a series of cell fate decisions to form a functional gland. The mechanisms that drive SMG organogenesis provide a template to regenerate functional salivary glands in patients who suffer from salivary hypofunction due to irreversible glandular damage after irradiation or removal of tumors. Additionally, these mechanisms may also control growth and development of other organ systems. WIREs Dev Biol 2012, 1:69–82. doi: 10.1002/wdev.4
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