Advanced Review

Calcium channels as therapeutic targets

  1. Francesco Belardetti1,2,
  2. Gerald W. Zamponi2,*

Article first published online: 24 JAN 2012

DOI: 10.1002/wmts.38

Issue

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling

Volume 1, Issue 4, pages 433–451, July/August 2012

Additional Information

How to Cite

Belardetti, F. and Zamponi, G. W. (2012), Calcium channels as therapeutic targets. WIREs Membr Transp Signal, 1: 433–451. doi: 10.1002/wmts.38

Author Information

  1. 1

    Department of Psychiatry, University of British Columbia, Vancouver, Canada

  2. 2

    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada

*Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada

Publication History

  1. Issue published online: 12 JUN 2012
  2. Article first published online: 24 JAN 2012

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (379K)

Abstract

Voltage gated calcium channels regulate numerous physiological functions, across a wide range of organ systems including heart, muscle, and brain. Different calcium channel subtypes have evolved to mediate specific cellular functions in these tissues. Because of their fundamental importance, voltage-gated calcium channels are targeted by a number of clinically active drugs (including gabapentin, pregabalin, ethosuximide, nimodipine, etc.) in conditions such as pain, epilepsy, and hypertension. In addition, calcium channels are emerging as targets for novel therapeutic indications. WIREs Membr Transp Signal 2012, 1:433–451. doi: 10.1002/wmts.38

For further resources related to this article, please visit the WIREs website.

View Full Article (HTML) Get PDF (379K)