Calcium channels as therapeutic targets
Article first published online: 24 JAN 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling
Volume 1, Issue 4, pages 433–451, July/August 2012
How to Cite
Belardetti, F. and Zamponi, G. W. (2012), Calcium channels as therapeutic targets. WIREs Membr Transp Signal, 1: 433–451. doi: 10.1002/wmts.38
- Issue published online: 12 JUN 2012
- Article first published online: 24 JAN 2012
Voltage gated calcium channels regulate numerous physiological functions, across a wide range of organ systems including heart, muscle, and brain. Different calcium channel subtypes have evolved to mediate specific cellular functions in these tissues. Because of their fundamental importance, voltage-gated calcium channels are targeted by a number of clinically active drugs (including gabapentin, pregabalin, ethosuximide, nimodipine, etc.) in conditions such as pain, epilepsy, and hypertension. In addition, calcium channels are emerging as targets for novel therapeutic indications. WIREs Membr Transp Signal 2012, 1:433–451. doi: 10.1002/wmts.38
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