These authors contributed equally.
Bioengineered nanoparticles for siRNA delivery
Article first published online: 2 JUL 2013
© 2013 Wiley Periodicals, Inc.
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Volume 5, Issue 5, pages 449–468, September/October 2013
How to Cite
Kozielski, K. L., Tzeng, S. Y. and Green, J. J. (2013), Bioengineered nanoparticles for siRNA delivery. WIREs Nanomed Nanobiotechnol, 5: 449–468. doi: 10.1002/wnan.1233
- Issue published online: 25 SEP 2013
- Article first published online: 2 JUL 2013
- NIH. Grant Number: 1R01EB016721
- NIH Cancer Nanotechnology Training Center. Grant Number: R25CA153952
- National Science Foundation
Short interfering RNA (siRNA) has been an important laboratory tool in the last two decades and has allowed researchers to better understand the functions of nonprotein-coding genes through RNA interference (RNAi). Although RNAi holds great promise for this purpose as well as for treatment of many diseases, efforts at using siRNA have been hampered by the difficulty of safely and effectively introducing it into cells of interest, both in vitro and in vivo. To overcome this challenge, many biomaterials and nanoparticles (NPs) have been developed and optimized for siRNA delivery, often taking cues from the DNA delivery field, although different barriers exist for these two types of molecules. In this review, we discuss general properties of biomaterials and nanoparticles that are necessary for effective nucleic acid delivery. We also discuss specific examples of bioengineered materials, including lipid-based NPs, polymeric NPs, inorganic NPs, and RNA-based NPs, which clearly illustrate the problems and successes in siRNA delivery. WIREs Nanomed Nanobiotechnol 2013. doi: 10.1002/wnan.1233
Conflict of interest: The authors have declared no conflicts of interest for this article.
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