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Recent progress in the development of polysaccharide conjugates of docetaxel and paclitaxel

Authors

  • Aniruddha Roy,

    1. Drug Delivery and Formulation, Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada
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  • Mousumi Bhattacharyya,

    1. Drug Delivery and Formulation, Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada
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  • Mark J. Ernsting,

    1. Drug Delivery and Formulation, Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada
    2. Faculty of Engineering and Architectural Science, Ryerson University, Toronto, ON, Canada
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  • Jonathan P May,

    1. Drug Delivery and Formulation, Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada
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  • Shyh-Dar Li

    Corresponding author
    1. Drug Delivery and Formulation, Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada
    2. Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
    3. The Techna Institute, University Health Network, Toronto, ON, Canada
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Abstract

Taxanes are one of the most potent and broadest spectrum chemotherapeutics used clinically, but also induce significant side effects. Different strategies have been developed to produce a safer taxane formulation. Development of polysaccharide drug conjugates has increased in the recent years because of the demonstrated biocompatibility, biodegradability, safety, and low cost of the biopolymers. This review focuses on polysaccharide–taxane conjugates and provides an overview on various conjugation strategies and their effect on the efficacy. Detailed analyses on the designing factors of an effective polysaccharide–drug conjugate are provided with a discussion on the future direction of this field.

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Conflict of interest: The authors have declared no conflicts of interest for this article.

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