Mucoadhesive nanosystems for vaginal microbicide development: friend or foe?
Article first published online: 19 APR 2011
Copyright © 2011 John Wiley & Sons, Inc.
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Volume 3, Issue 4, pages 389–399, July/August 2011
How to Cite
das Neves, J., Amiji, M. and Sarmento, B. (2011), Mucoadhesive nanosystems for vaginal microbicide development: friend or foe?. WIREs Nanomed Nanobiotechnol, 3: 389–399. doi: 10.1002/wnan.144
- Issue published online: 7 JUN 2011
- Article first published online: 19 APR 2011
Topical microbicides are a promising strategy in the prevention of vaginal and rectal HIV transmission as well as other sexually transmitted pathogens. The perspective of developing nanotechnology-based systems for topical microbicides seems to be useful because important features such as enhanced drug release, targeting, and epithelial penetration can be achieved. However, the interaction of nanoparticles with the mucus fluids that cover the cervicovaginal mucosal epithelium, which can work either as a docking point or as a barrier for diffusion, has been frequently neglected. In this review, we discuss the principles of nanosystems' adhesion to the mucosal tissue and how this relates to the development of optimized microbicide formulations. WIREs Nanomed Nanobiotechnol 2011 3 389–399 DOI: 10.1002/wnan.144
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