Advanced Review

Top-down particle fabrication: control of size and shape for diagnostic imaging and drug delivery

  1. Dorian A. Canelas1,
  2. Kevin P. Herlihy1,
  3. Joseph M. DeSimone1,2,3,4,*

Article first published online: 26 MAY 2009

DOI: 10.1002/wnan.40

Issue

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology

Volume 1, Issue 4, pages 391–404, July/August 2009

Additional Information

How to Cite

Canelas, D. A., Herlihy, K. P. and DeSimone, J. M. (2009), Top-down particle fabrication: control of size and shape for diagnostic imaging and drug delivery. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 1: 391–404. doi: 10.1002/wnan.40

Author Information

  1. 1

    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

  2. 2

    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

  3. 3

    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA

  4. 4

    Department of Chemical Engineering, North Carolina State University, Raleigh, NC 27695, USA

*Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

Publication History

  1. Issue published online: 17 JUN 2009
  2. Article first published online: 26 MAY 2009

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Abstract

This review discusses rational design of particles for use as therapeutic vectors and diagnostic imaging agent carriers. The emerging importance of both particle size and shape is considered, and the adaptation and modification of soft lithography methods to produce nanoparticles are highlighted. To this end, studies utilizing particles made via a process called Particle Replication In Non-wetting Templates are discussed. In addition, insights gained into therapeutic cargo and imaging agent delivery from related types of polymer-based carriers are considered. Copyright © 2009 John Wiley & Sons, Inc.

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