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Focus Article
MicroRNA degradation and turnover: regulating the regulators
Article first published online: 28 MAR 2012
DOI: 10.1002/wrna.1114
Copyright © 2012 John Wiley & Sons, Ltd.
Additional Information
How to Cite
Zhang, Z., Qin, Y.-W., Brewer, G. and Jing, Q. (2012), MicroRNA degradation and turnover: regulating the regulators. WIREs RNA, 3: 593–600. doi: 10.1002/wrna.1114
Publication History
- Issue published online: 12 JUN 2012
- Article first published online: 28 MAR 2012
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Abstract
MicroRNAs (miRNAs) are endogenous, small noncoding RNAs that play important regulatory roles in gene expression. The control of miRNA biogenesis has been well characterized, but their degradation is not fully understood. Recent discoveries indicate that miRNAs have a long life span in general. However, rapid turnover dynamics of miRNAs in a variety of specific cellular contexts has been documented, as well as the requirement of sequence elements for miRNA decay. Furthermore, several ribonucleases that degrade miRNAs have been identified. Here, we discuss the cellular contexts and biochemical mechanisms of miRNA decay, together with several prominent questions in this field. WIREs RNA 2012, 3:593–600. doi: 10.1002/wrna.1114
For further resources related to this article, please visit the WIREs website.
The authors declare no conflict of interest.