Transfer RNA-derived fragments: origins, processing, and functions

Authors

  • Andrew Sobala,

    1. Wellcome Trust Centre for Gene Regulation and Expression, Dundee University, Dundee, UK
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  • Gyorgy Hutvagner

    Corresponding author
    1. Wellcome Trust Centre for Gene Regulation and Expression, Dundee University, Dundee, UK
    2. Centre for Health Technologies, University of Technology, Sydney, Australia
    • Wellcome Trust Centre for Gene Regulation and Expression, Dundee University, Dundee, UK
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Abstract

Deep sequencing approaches have revealed multiple types of small RNAs with known and unknown functions. In this review we focus on a recently identified group of small RNAs that are derived from transfer RNAs (tRNAs), tRNA fragments (tRFs). We review the mechanism of their processing and their functions in mammalian cells, and highlight points of possible cross-talk between tRFs and the canonical small RNA pathway characterized by small interfering RNAs (siRNAs), microRNAs (miRNAs), and Piwi-interacting RNAs (piRNAs). We also propose a nomenclature that is based on their processing characteristics. WIREs RNA 2011 2 853–862 DOI: 10.1002/wrna.96

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