Transfer RNA-derived fragments: origins, processing, and functions
Article first published online: 30 JUN 2011
Copyright © 2011 John Wiley & Sons, Ltd.
Wiley Interdisciplinary Reviews: RNA
Volume 2, Issue 6, pages 853–862, November/December 2011
How to Cite
Sobala, A. and Hutvagner, G. (2011), Transfer RNA-derived fragments: origins, processing, and functions. WIREs RNA, 2: 853–862. doi: 10.1002/wrna.96
- Issue published online: 4 OCT 2011
- Article first published online: 30 JUN 2011
Deep sequencing approaches have revealed multiple types of small RNAs with known and unknown functions. In this review we focus on a recently identified group of small RNAs that are derived from transfer RNAs (tRNAs), tRNA fragments (tRFs). We review the mechanism of their processing and their functions in mammalian cells, and highlight points of possible cross-talk between tRFs and the canonical small RNA pathway characterized by small interfering RNAs (siRNAs), microRNAs (miRNAs), and Piwi-interacting RNAs (piRNAs). We also propose a nomenclature that is based on their processing characteristics. WIREs RNA 2011 2 853–862 DOI: 10.1002/wrna.96
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