Modeling cellular compartmentation in one-carbon metabolism
Version of Record online: 13 FEB 2013
Copyright © 2013 Wiley Periodicals, Inc.
Wiley Interdisciplinary Reviews: Systems Biology and Medicine
Volume 5, Issue 3, pages 343–365, May/June 2013
How to Cite
Scotti, M., Stella, L., Shearer, E. J. and Stover, P. J. (2013), Modeling cellular compartmentation in one-carbon metabolism. WIREs Syst Biol Med, 5: 343–365. doi: 10.1002/wsbm.1209
- Issue online: 10 APR 2013
- Version of Record online: 13 FEB 2013
Folate-mediated one-carbon metabolism (FOCM) is associated with risk for numerous pathological states including birth defects, cancers, and chronic diseases. Although the enzymes that constitute the biological pathways have been well described and their interdependency through the shared use of folate cofactors appreciated, the biological mechanisms underlying disease etiologies remain elusive. The FOCM network is highly sensitive to nutritional status of several B-vitamins and numerous penetrant gene variants that alter network outputs, but current computational approaches do not fully capture the dynamics and stochastic noise of the system. Combining the stochastic approach with a rule-based representation will help model the intrinsic noise displayed by FOCM, address the limited flexibility of standard simulation methods for coarse-graining the FOCM-associated biochemical processes, and manage the combinatorial complexity emerging from reactions within FOCM that would otherwise be intractable. WIREs Syst Biol Med 2013, 5:343–365. doi: 10.1002/wsbm.1209
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