Toward a complete in silico, multi-layered embryonic stem cell regulatory network
Article first published online: 24 MAR 2010
Copyright © 2010 John Wiley & Sons, Inc.
Wiley Interdisciplinary Reviews: Systems Biology and Medicine
Volume 2, Issue 6, pages 708–733, November/December 2010
How to Cite
Xu, H., Schaniel, C., Lemischka, I. R. and Ma'ayan, A. (2010), Toward a complete in silico, multi-layered embryonic stem cell regulatory network. WIREs Syst Biol Med, 2: 708–733. doi: 10.1002/wsbm.93
- Issue published online: 24 MAR 2010
- Article first published online: 24 MAR 2010
Recent efforts in systematically profiling embryonic stem (ES) cells have yielded a wealth of high-throughput data. Complementarily, emerging databases and computational tools facilitate ES cell studies and further pave the way toward the in silico reconstruction of regulatory networks encompassing multiple molecular layers. Here, we briefly survey databases, algorithms, and software tools used to organize and analyze high-throughput experimental data collected to study mammalian cellular systems with a focus on ES cells. The vision of using heterogeneous data to reconstruct a complete multi-layered ES cell regulatory network is discussed. This review also provides an accompanying manually extracted dataset of different types of regulatory interactions from low-throughput experimental ES cell studies available at http://amp.pharm.mssm.edu/iscmid/literature. Copyright © 2010 John Wiley & Sons, Inc.
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