Role of the N-terminal region of Rap1p in the transcriptional activation of glycolytic genes in Saccharomyces cerevisiae
Article first published online: 3 AUG 2004
Copyright © 2004 John Wiley & Sons, Ltd.
Volume 21, Issue 10, pages 851–866, 30 July 2004
How to Cite
Mizuno, T., Kishimoto, T., Shinzato, T., Haw, R., Chambers, A., Wood, J., Sinclair, D. and Uemura, H. (2004), Role of the N-terminal region of Rap1p in the transcriptional activation of glycolytic genes in Saccharomyces cerevisiae. Yeast, 21: 851–866. doi: 10.1002/yea.1123
- Issue published online: 3 AUG 2004
- Article first published online: 3 AUG 2004
- Manuscript Accepted: 6 FEB 2004
- Manuscript Received: 22 DEC 2003
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- British Council
- UK/Japan Joint Grant (Royal Society, UK)
- 1986. Glycolytic gene expression in Saccharomyces cerevisiae: nucleotide sequence of GCR1, null mutants, and evidence for expression. Mol Cell Biol 6: 3774–3784. .
- 1991. GCR1 of Saccharomyces cerevisiae encodes a DNA binding protein whose binding is abolished by mutations in the CTTCC sequence motif. Proc Natl Acad Sci USA 88: 9443–9447. .
- 1993a. Using the two-hybrid system to detect protein–protein interactions. In Cellular Interactions in Development: A Practical Approach, HartleyDA (ed). Oxford University Press: Oxford; 1. , , , .
- 1993b. Elimination of false positives that arise in using the two-hybrid system. Bio Techniques 14: 920–924. , , , .
- 1997. A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J 11: 68–76. , , , et al.
- 1990. Multiple factors bind the upstream activation sites of the yeast enolase genes ENO1 and ENO2: ABF1 protein, like repressor activator protein RAP1, binds cis-acting sequences which modulate repression or activation of transcription. Mol Cell Biol 10: 4872–4885. , , , , .
- 1988. Connections between transcriptional activators, silencers, and telomeres as revealed by functional analysis of a yeast DNA-binding protein. Mol Cell Biol 8: 5086–5099. , , .
- 1997. From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. FEBS Lett 400: 25–30. , .
- 1989. Transcriptional control of the Saccharomyces cerevisiae PGK gene by RAP1. Mol Cell Biol 9: 5516–5524. , , , , .
- 1995. Control of glycolytic gene expression in the budding yeast (Saccharomyces cerevisiae). Curr Genet 1: 1–9. , , .
- 1990. ARS binding factor 1 binds adjacent to RAP1 at the UASs of the yeast glycolytic genes PGK and PYK1. Nucleic Acids Res 18: 5393–5399. , , , et al.
- 1990. A yeast protein that influences the chromatin structure of UASG and functions as a powerful auxiliary gene activator. Genes Dev 4: 503–514. , , , et al.
- 1991. The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest. Proc Natl Acad Sci USA 88: 9578–9582. , , , .
- 1981. The gcr (glycolysis regulation) mutation of Saccharomyces cerevisiae. J Biol Chem 256: 13 074–13 078. , .
- 2001. Rap1p requires Gcr1p and Gcr2p homodimers to activate ribosomal protein and glycolytic genes, respectively. Genetics 158: 133–143. , .
- 1995. Unigenic evolution: a novel method localizes a putative leucine zipper that mediates dimerization of the Saccharomyces cerevisiae regulator Gcr1p. Genetics 141: 1263–1274. , , .
- 1996. Activation mechanism of the multifunctional transcriptional factor repressor–activator protein (Rap1). Mol Cel Biol 16: 3187–3196. , , , .
- 1982. Carbohydrate metabolism. In The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, StrahernJN, JonesELS, BroachJR (eds). Cold Spring Harbor Laboratory Press New York; 1–37. .
- 1994. Homeodomain-DNA recognition. Cell 78: 211–223. , , , et al.
- 1991. The role of RAP1 in the regulation of the MAT locus. Mol Cell Biol 11: 1069–1079. , , .
- 1993. Distortion of the DNA double helix by RAP1 at silencers and multiple telomeric binding sites. J Mol Biol 231: 293–310. , , , , .
- 1996. C-Terminal domains of general regulatory factors Abf1p and Rap1p in Saccharomyces cerevisiae display functional similarity. Mol Microbiol 19: 535–554. , , , et al.
- 1999. In vivo analysis of functional regions within yeast Rap1p. Mol Cell Biol 19: 7481–7490. , , , , .
- 1992a. Dissection of a carboxy-terminal region of the yeast regulatory protein RAP1 with effects on both transcriptional activation and silencing. Mol Cell Biol 12: 1209–1217. , , .
- 1992b. A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev 6: 801–814. , , .
- 2001. Isolation of a Candida glabrata homologue of RAP1, a regulator of transcription and telomere function in Saccharomyces cerevisiae. Yeast 18: 1277–1284. , , .
- 1994. The yeast protein Gcr1p binds to the PGK UAS and contributes to the activation of transcription of the PGK gene. Mol Gen Genet 245: 506–511. , , , et al.
- 1986. Related articles, nucleotide, protein yeast–E. coli shuttle vectors with multiple unique restriction sites. Yeast 2: 163–167. , , , .
- 1987. A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. Gene 57: 267–272. , .
- 1994. Rapid protein extraction from Saccharomyces cerevisiae. Yeast 10: 1305–1310. , .
- 1985. A general upstream binding factor for genes of the yeast translational apparatus. EMBO J 4: 3539–3547. , , , et al.
- 1992. Characterization of the DNA-binding activity of GCR1: in vivo evidence for two GCR1-binding sites in the upstream activating sequence of TPI of Saccharomyces cerevisiae. Mol Cell Biol 12: 2690–2700. , , , et al.
- 1983. Transformation of intact yeast cells treated with alkali cations. J Bacteriol 153: 163–168. , , , , .
- 1982. Cloning of yeast glycolysis genes by complementation. Biochem Biophys Res Commun 108: 1107–1112. , .
- 1996. The crystal structure of the DNA binding domain of yeast RAP1 in complex with telomeric DNA. Cell 85: 125–136. , , , .
- 1996. BRCA1 protein products functional motifs. Nature Genet 13: 266–268. , , .
- 1991. RAP1 protein activates and silences transcription of mating type genes in yeast. Genes Dev 5: 616–628. , .
- 2001. Promoter-specific binding of Rap1 revealed by genome-wide maps of protein–DNA association. Nature Genet 28: 327–334. , , , .
- 1998. Multiple domains of repressor activator protein 1 contribute to facilitated binding of glycolysis regulatory protein 1. Proc Natl Acad USA 95: 14 112–14 117. , , .
- 2000. Understanding the growth phenotype of the yeast gcr1 mutant in terms of global genomic expression patterns. J Bacteriol 182: 4970–4978. , .
- 1971. A kinetic study of glycolytic enzyme synthesis in yeast. J Biol Chem 264: 475–488. , .
- 2003. Gall1 is a general activator of basal transcription, whose activity is regulated by the general repressor Sin4 in yeast. Mol Genet Genom 269: 68–77. , .
- 2000. A functional comparison of BRCA1 C-terminal domains in transcription activation and chromatin remodeling. J Biol Chem 275: 40 169–40 173. , , , .
- 1994. Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1. Genes Dev 8: 2257–2269. , , , .
- 1989. Proteins that bind to the yeast rDNA enhancer. J Biol Chem 264: 9061–9068. , , .
- 1994. Imaging the asymmetrical DNA bend induced by repressor activator protein 1 with scanning tunneling microscopy. J Struct Biol 113: 1–12. , , , et al.
- 1994. Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices. Cell 79: 639–648. , , , et al.
- 1996. The multifunctional transcription factors Abf1p, Rap1p and Reb1p are required for full transcriptional activation of the chromosomal PGK gene in Saccharomyces cerevisiae. Mol Gen Genet 250: 348–356. , , .
- 1989. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press: New York. , , .
- 1999. The E-box DNA binding protein Sgc1p suppresses the gcr2 mutation, which is involved in transcriptional activation of glycolytic genes in Saccharomyces cerevisiae. FEBS Lett 463: 307–311. , , , et al.
- 1993. Concerted action of the transcriptional activators REB1, RAP1, and GCR1 in the high-level expression of the glycolytic gene TPI. Mol Cell Biol 13: 543–550. , .
- 1986. Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press: New York. , , .
- 1987. Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements. Cell 51: 721–732. , .
- 1994. RAP1: a protean regulator in yeast. Trends Genet 10: 408–412. .
- 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19–27. , .
- 1991. Separation of transcriptional activation and silencing function of the RAP1-encoded repressor/activator protein 1: isolation of viable mutant affecting both silencing and telomere length. Proc Natl Acad Sci USA 88: 7749–7753. , .
- 1993. GCR1, a transcriptional activator in Saccharomyces cerevisiae, complexes with RAP1 and can function without its DNA binding domain. EMBO J 12: 2431–2437. , , , .
- 1997. GCR1-dependent transcriptional activation of yeast retrotransposon Ty2-917. Yeast 13: 917–930. , , .
- 1987. A positive regulatory sequence of the Saccharomyces cerevisiae ENO1 gene. J Biochem Tokyo 102: 181–189. , , , et al.
- 1988. Suppression of chromosomal mutations affecting M1 virus replication in Saccharomyces cerevisiae by a variant of a viral RNA segment (L–A) that encodes coat protein. Mol Cell Biol 8: 938–944. , .
- 1990. gcr2, a new mutation affecting glycolytic gene expression in Saccharomyces cerevisiae. Mol Cell Biol 10: 6389–6396. , .
- 1992. Role of GCR2 in transcriptional activation of yeast glycolytic genes. Mol Cell Biol 12: 3834–3842. , .
- 1995. Mutations in GCR1, a transcriptional activator of Saccharomyces cerevisiae glycolytic genes, function as suppressors of gcr2 mutations. Genetics 139: 511–521. , .
- 1997. The role of Gcr1p in the transcriptional activation of glycolytic genes in yeast Saccharomyces cerevisiae. Genetics 147: 521–532. , , , , .
- 1999. Glucose metabolism in gcr mutants of Saccharomyces cerevisiae. J Bacteriol 181: 4719–4723. , .
- 1989. Asymmetric DNA bending induced by the yeast multifunctional factor TUF. J Biol Chem 264: 8463–8466. , .
- 1994. New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10: 1793–1808. , , , .
- 2002. Analysis of the RAP1 protein binding to homogeneous telomeric repeats in Saccharomyces castellii. Yeast 19: 241–256. , .
- 1993. A complex regulatory element from the yeast gene ENO2 modulates GCR1-dependent transcriptional activation. Mol Cell Biol 13: 2623–2633. , , .
- 1997. Novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae. Genes Dev 11: 748–760. , .