Modelling dynamic processes in yeast
Article first published online: 17 SEP 2007
Copyright © 2007 John Wiley & Sons, Ltd.
Volume 24, Issue 11, pages 943–959, November 2007
How to Cite
Klipp, E. (2007), Modelling dynamic processes in yeast. Yeast, 24: 943–959. doi: 10.1002/yea.1544
- Issue published online: 24 OCT 2007
- Article first published online: 17 SEP 2007
- Manuscript Accepted: 15 JUL 2007
- Manuscript Received: 19 FEB 2007
- European Community. Grant Numbers: FP6-2004-LSH-5 # 018942, LSHG-CT2003-530203
Yeast molecular and cell biology has accumulated large amounts of qualitative and quantitative data of diverse cellular processes. The results are often summarized as verbal or graphical descriptions. Moreover, a series of mathematical models has been developed that should help to interpret such data, to integrate them into a coherent picture and to allow for an understanding of the underlying processes. Dynamic modelling of regulatory processes in yeast focuses on central carbon metabolism, on a number of selected signalling pathways and on cell cycle regulation. These models can explain questions of general relevance, such as whether the dynamics of a network can be understood from the combination of in vitro kinetics of its individual reactions. They help to elucidate complicated dynamic features, such as glycolytic oscillations, effects of feedback regulation or the optimal regulation of gene expression. The availability of comprehensive qualitative information, such as protein interactions or pathway composition, and sets of quantitative data make yeast a perfect model organism. Therefore, yeast-related data are often used to develop and examine computational approaches and modelling methods. Copyright © 2007 John Wiley & Sons, Ltd.