Dr. Michelle Davis's present address is The Chicago Zoo and Aquatic Animal Veterinary Residency Program, Chicago, Illinois.
Evaluation of intramuscular ketoprofen and butorphanol as analgesics in chain dogfish (Scyliorhinus retifer)†
Article first published online: 26 JUL 2006
© 2006 Wiley-Liss, Inc.
Volume 25, Issue 6, pages 491–500, November/December 2006
How to Cite
Davis, M. R., Mylniczenko, N., Storms, T., Raymond, F. and Dunn, J. L. (2006), Evaluation of intramuscular ketoprofen and butorphanol as analgesics in chain dogfish (Scyliorhinus retifer). Zoo Biol., 25: 491–500. doi: 10.1002/zoo.20105
- Issue published online: 20 DEC 2006
- Article first published online: 26 JUL 2006
- Manuscript Accepted: 23 MAR 2006
- Manuscript Received: 13 FEB 2006
The mediation of nociception with analgesic medications has not been well documented in elasmobranchs. The purpose of this study was to determine effective analgesic doses of the opioid agonist-antagonist, butorphanol, and the non-steroidal anti-inflammatory drug, ketoprofen, in an elasmobranch. This was evaluated by repetitively assessing minimum anesthetic concentrations of the immersion anesthetic, tricaine methanesulfonate (MS-222), required to prevent response to noxious stimuli in chain dogfish (Scyliorhinus retifer) when administered multiple doses of each of the analgesics (0.25, 0.5, 1.0, 2.5, and 5.0 mg/kg butorphanol and 1.0, 1.5, 2.0, and 4.0 mg/kg ketoprofen). Baseline concentrations of MS-222 required to prevent a response to a noxious stimulus were determined for each animal and served as the controls. Although individual animals displayed a reduction in MS-222 concentration with various doses of both analgesics, no statistically significant difference was noted between control animals and animals given analgesics. It is plausible that unique elasmobranch anatomy, lack of appropriate medication dose or timing of administration, and other physiological factors not yet identified may have contributed to the lack of apparent efficacy of the analgesics evaluated in this study. Zoo Biol 0:1–10, 2006. © 2006 Wiley-Liss, Inc.