Estrogen-regulated expression of a growth arrest specific gene (gas-1) in rat uterus
Article first published online: 2 JAN 2013
© The Author(s) Journal compilation © 1993 International Federation for Cell Biology
Cell Biology International
Volume 17, Issue 9, pages 857–862, September 1993
How to Cite
Ferrero, M. and Cairo, G. (1993), Estrogen-regulated expression of a growth arrest specific gene (gas-1) in rat uterus. Cell Biology International, 17: 857–862. doi: 10.1006/cbir.1993.1148
- Issue published online: 2 JAN 2013
- Article first published online: 2 JAN 2013
- Paper received 25.05.93. Revised paper accepted 30.07.93.
- Cited By
gas-1 belongs to a family of growth arrest specific genes negatively regulated after growth induction of arrested cells. We report the expression of gas-1 in an in vivo system of cell proliferation. gas-1 mRNA accumulates progressively in the uterus of ovariectomized rats with a peak at three weeks after surgery. After estrogen treatment gas-1 mRNA levels decrease within two hours, at a time when c-myc expression is greatly increased, and return to pretreatment levels at 48 hours. Treatment with cycloheximide does not prevent estrogen-induced down-regulation of gas-1 mRNA levels. The present results show that: i) estrogen affects the uterine growth state by regulating the expression of both positively and negatively acting genes, ii) gas-1 expression is controlled by cellular growth state also in vivo.