In vitro studies on chemoprotective effect of purnark against benzo(a)pyrene-induced chromosomal damage in human lymphocytes.
Article first published online: 2 JAN 2013
© The Author(s) Journal compilation © 1994 International Federation for Cell Biology
Cell Biology International
Volume 18, Issue 1, pages 21–27, January 1994
How to Cite
Ghaisas, S. D. and Bhide, S. V. (1994), In vitro studies on chemoprotective effect of purnark against benzo(a)pyrene-induced chromosomal damage in human lymphocytes. Cell Biology International, 18: 21–27. doi: 10.1006/cbir.1994.1003
- Issue published online: 2 JAN 2013
- Article first published online: 2 JAN 2013
- Paper received 29.07.93. Revised paper accepted 03.12.93.
- Cited By
Human lymphocytes were used as an assay system to test chemopreventive activity of natural products. Purnark, a mixture of extracts of turmeric, betel leaf and catechu, was tested for its chemoprotective activity against BP induced DNA damage. Sister chromatid exchange and micronuclei were used as markers to assess the protective activity of Purnark. Purnark gave 50-60 % protection against BP induced SCEs and micronuclei. Purnark at 1000μg dose did not show any genotoxicity.