Studies on bcl-2 protein in cultured lymphoid cells.
Article first published online: 2 JAN 2013
© The Author(s) Journal compilation © 1994 International Federation for Cell Biology
Cell Biology International
Volume 18, Issue 2, pages 95–102, February 1994
How to Cite
Filip, A. and Rożynkowa, D. (1994), Studies on bcl-2 protein in cultured lymphoid cells. Cell Biology International, 18: 95–102. doi: 10.1006/cbir.1994.1048
- Issue published online: 2 JAN 2013
- Article first published online: 2 JAN 2013
- Paper received 31.12.93. Paper accepted 21.01.94.
- Cited By
Bc1-2 protein was analysed in cell cultures derived from non-Hodgkin lymphomas and chronic lymphocytic leukaemia patients. The presence of bc1-2 proto-oncogene protein product has been demonstrated on cytospin preparations utilising immunochemical methods. The correlation between the expression of the bc1-2 protein and the appearance of proliferation- or differentiation related figures was studied. The reported bc1-2 up regulation in malignant lymphoid cells was confirmed in haemo- and lymphopoietic progenitor cells as well as in TPA/PHA activated peripheral blood lymphocytes. In comparison to neoplastic cells lower intensity of bc1-2 positive staining in freshly isolated cells from non-leukaemic tissue was observed.