The control of Ca2+ homeostasis: role of intracellular rapidly exchanging Ca2+ stores.

Authors

  • Antonello Villa,

    1. Dept of Pharmacology, CNR and B. Ceccarelli Centers and DIBIT, Scientific Institute S. Raffaele
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  • Jacopo Meldolesi

    Corresponding author
    1. Dept of Pharmacology, CNR and B. Ceccarelli Centers and DIBIT, Scientific Institute S. Raffaele
      Corresponding author (DIBIT Scientific Institute S. Raffaele, Via Olgettina, 60,20132 Milano)
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Corresponding author (DIBIT Scientific Institute S. Raffaele, Via Olgettina, 60,20132 Milano)

ABSTRACT

The role of rapidly exchanging intracellular Ca2+ stores in the control of Ca2+ homeostasis is reviewed. The following issues are discussed: the reasons why such stores exist in eukaryotic cells; the differences between the terminal cisternae of the skeletal muscle sarcoplasmic reticulum, which have direct, physical connection with the T tubules of the plasmalemma, and the Ca2+ stores located in the depth of the cytoplasm, which are stimulated by second messengers; the cytological nature (subcompartments of the ER) of the rapidly exchanging Ca2+ stores and their functional significance. The conclusions introduce recent developments in which intracellular Ca2+ stores have been investigated also by molecular biology techniques.

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