GLUCOSE STRONGLY STIMULATES RATE OF THE RRNA SYNTHESIS IN EHRLICH ASCITES CARCINOMA CELLS

Authors

  • I. M. Buzhurina,

    1. Laboratory of Cell Physiology, A. N. Belozersky Institute of Physical and Chemical Biology, Moscow State University, 119899 Moscow, Russia.
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  • N. G. Chernaya,

    1. Laboratory of Cell Physiology, A. N. Belozersky Institute of Physical and Chemical Biology, Moscow State University, 119899 Moscow, Russia.
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  • M. A. Panov

    Corresponding author
    1. Laboratory of Cell Physiology, A. N. Belozersky Institute of Physical and Chemical Biology, Moscow State University, 119899 Moscow, Russia.
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Laboratory of Cell Physiology, A. N. Belozersky Institute of Physical and Chemical Biology, Moscow State University, 119899 Moscow, Russia

ABSTRACT

A change in glucose concentration in an Ehrlich ascites carcinoma cell suspension from 0.1 mM to 20 mM causes a more than 50-fold stimulation of the rate of ribosomal RNA synthesis. Such an effect occurs without any dramatic effect on the rate of protein synthesis in cells. This process parallels a decrease in intracellular pH which may be a reason of Na+/H+-antiport activation.

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