The influence of maternal nicotine exposure on the interalveolar septal status of neonatal rat lung.
Version of Record online: 2 JAN 2013
© The Author(s) Journal compilation © 1994 International Federation for Cell Biology
Cell Biology International
Volume 18, Issue 7, pages 747–757, July 1994
How to Cite
Maritz, G. S. and Thomas, R.-A. (1994), The influence of maternal nicotine exposure on the interalveolar septal status of neonatal rat lung. Cell Biology International, 18: 747–757. doi: 10.1006/cbir.1994.1104
- Issue online: 2 JAN 2013
- Version of Record online: 2 JAN 2013
- Paper received 22.03.94. Revised paper accepted 20.05.94.
- Cited By
The aim of this study was to determine the effect of maternal nicotine exposure (1 mg nicotine/kg body mass/day, subcutaneously) on the status of the alveolar septa of the 1 to 21 day old offspring. The data obtained showed swelling of type II and interstitial cell mitochondria. The type I:type II cell ratio decreased as a result of type II cell proliferation. The number of capillaries per unit length of septum was also significantly lower than that of control lung. Ruptured blood-air barriers also occur in the nicotine exposed lungs of rats of all age groups. The results show that maternal nicotine exposure interfered with the morphometric and morphologic characteristics of the septa of lung tissue of the offspring.