Uncoordinate expressions of type I and III collagens, collagenase and tissue inhibitor of matrix metalloproteinase 1 along in vitro proliferative life span of human skin fibroblasts
Regulation by all-trans retinoic acid.
Article first published online: 2 JAN 2013
© The Author(s) Journal compilation © 1995 International Federation for Cell Biology
Cell Biology International
Volume 19, Issue 2, pages 129–136, February 1995
How to Cite
Bizot-Foulon, V., Bouchard, B., Hornebeck, W., Dubertret, L. and Bertaux, B. (1995), Uncoordinate expressions of type I and III collagens, collagenase and tissue inhibitor of matrix metalloproteinase 1 along in vitro proliferative life span of human skin fibroblasts. Cell Biology International, 19: 129–136. doi: 10.1006/cbir.1995.1053
- Issue published online: 2 JAN 2013
- Article first published online: 2 JAN 2013
- Paper received 18.11.94. Paper accepted 09.01.95.
- Cited By
- TIMP-1 (Tissue inhibitor of matrix metalloproteinase 1);
- Retinoic acid
In vitro human skin fibroblasts aging was characterized by a continuous increase of collagenase mRNA levels. On the contrary, TIMP-1 mRNA level decreased only at late passages (> 65% of proliferative life span). Type I and III mRNA levels showed a high variability depending on cell strains studied. However, type I and III collagen expressions varied parallely. All-trans retinoic acid (RA) decreased collagenase expression and stimulated TIMP-1 expression. Under RA action, high variability in mRNAs levels encoding type I and III collagens was observed with HSF passages. However, RA tended to correct variations in collagens expressions observed along HSF life span.