Transforming growth factor-beta 3.
Article first published online: 2 JAN 2013
© The Author(s) Journal compilation © 1995 International Federation for Cell Biology
Cell Biology International
Volume 19, Issue 5, pages 357–371, May 1995
How to Cite
Cox, D. A. (1995), Transforming growth factor-beta 3. Cell Biology International, 19: 357–371. doi: 10.1006/cbir.1995.1082
- Issue published online: 2 JAN 2013
- Article first published online: 2 JAN 2013
- Cited By
Transforming Growth Factor-Beta (TGF-β) is the general name for a family of naturally-occurring polypeptides which have multiple regulatory effects on cell proliferation and differentiation. Over the last decade it has become apparent that TGF-βs can be produced by most cell types and exert a wide range of effects in a context-dependent autocrine, paracrine or endocrine fashion via interactions with distinct receptors on the cell surface. This review summarizes current knowledge concerning the molecular and cellular biology of TGF-β3, the most recently described mammalian isoform, and focuses on those physiological actions which may lead to clinical applications, particularly in the indication areas of wound healing and chemoprotection.