Transforming growth factor alpha.
Version of Record online: 2 JAN 2013
© The Author(s) Journal compilation © 1995 International Federation for Cell Biology
Cell Biology International
Volume 19, Issue 5, pages 373–388, May 1995
How to Cite
Kumar, V., Bustin, S. A. and McKay, I. A. (1995), Transforming growth factor alpha. Cell Biology International, 19: 373–388. doi: 10.1006/cbir.1995.1083
- Issue online: 2 JAN 2013
- Version of Record online: 2 JAN 2013
- Cited By
Transforming growth factor alpha (TGFα) is a close relative of epidermal growth factor (EGF), the first polypeptide mitogen discovered in 1962 (Cohen, 1962). TGFα, like EGF, exerts its effect on cells through binding to the EGF-Receptor (EGF-R). Here we review the molecular and cell biology of TGFα before proceeding to describe our own work on signaling molecules induced in response to activation of the EGF-R.