The effect of cisplatin and transplatin on the conformation and association of F-actin.
Version of Record online: 2 JAN 2013
© The Author(s) Journal compilation © 1995 International Federation for Cell Biology
Cell Biology International
Volume 19, Issue 6, pages 491–498, June 1995
How to Cite
Hui, Z. H., Fen, L. J. and Kui, W. (1995), The effect of cisplatin and transplatin on the conformation and association of F-actin. Cell Biology International, 19: 491–498. doi: 10.1006/cbir.1995.1093
- Issue online: 2 JAN 2013
- Version of Record online: 2 JAN 2013
- Cited By
The effects of cisplatin and transplatin on the conformation and association of F-actin were studied by ESR, turbidimetry and CD measurement. The results indicate that the major component affecting F-actin secondary conformation is derived from their effect on the tertiary or quaternary conformation and association states of F-actin. The effect of platinum is seen by the fact that binding of cisplatin causes first an increase in molecular size followed by a later decrease. The induction time for the association depended on the concentration of cisplatin. Transplatin was able to reach the target site more readily, resulting in the dissociation of F-actin even at a very low concentration.