Predoctoral fellow: Interdepartmental Training Grant in the Pharmacological Sciences, NIH/NIGMS Grant No. GM07767.
IMMUNOCHEMICAL IDENTIFICATION OF THE 1,25-DIHYDROXYVITAMIN D3RECEPTOR PROTEIN IN HUMAN HEART
Article first published online: 2 JAN 2013
© The Author(s) Journal compilation © 1996 International Federation for Cell Biology
Cell Biology International
Volume 20, Issue 9, pages 621–624, September 1996
How to Cite
O'CONNELL, T. D. and SIMPSON, R. U. (1996), IMMUNOCHEMICAL IDENTIFICATION OF THE 1,25-DIHYDROXYVITAMIN D3RECEPTOR PROTEIN IN HUMAN HEART. Cell Biology International, 20: 621–624. doi: 10.1006/cbir.1996.0081
- Issue published online: 2 JAN 2013
- Article first published online: 2 JAN 2013
- Accepted 9 July 1996
- Cited By
- vitamin D;
- human heart
A number of recent clinical observations suggest that vitamin D3plays an important role in maintaining normal cardiovascular function, either directly through its receptor in cardiac muscle, or indirectly through its infuence on circulating levels of calcium or on other regulatory factors. By using an antibody directed against the recombinant vitamin D3receptor, we have identified the receptor protein for 1,25(OH)2D3in tissue from two human hearts. The identification of the 1,25(OH)2D3receptor in human heart lends credence to the hypothesis that 1,25(OH)2D3directly effects the human heart and may be involved in several clinically relevant pathological conditions involving the vitamin D3endocrine system.