KINESIN-ASSOCIATED TRANSPORT IS INVOLVED IN THE REGULATION OF CELL ADHESION

Authors


To whom correspondence should be addressed: (present address) Institute of Molecular Biology, Austrian Academy of Sciences, Billrothstr. 11, A/5020, Salzburg, Austria

Abstract

It has been recently shown that depolymerization of microtubules induces the elongation of focal contacts at the leading edge. On the other hand, cell shape and pseudopodial activity were found to depend on the microtubule-based motor kinesin. In this paper, we examine whether kinesin is involved in controlling the dynamics of adhesive structures at the cell surface. Microinjection of an antiblocking kinesin activityin vitrocauses focal contact elongation similar to the effect of microtubule-depolymerizing drugs. Thus, the role of microtubules in cell adhesion lies in the supporting kinesin-based transport to the adhesion sites.

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