APHIDICOLIN INHIBITS DNA REPLICATION IN THE MICRONUCLEUS AND BLOCKS CYTOKINESIS IN PARAMECIUM CAUDATUM

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Abstract

Aphidicolin, a selective inhibitor of DNA polymerase, totally blocks DNA replication in the micronucleus but not in the macronucleus of Paramecium caudatum. The ciliates no longer divide and after 4 days the DNA content of the macronucleus has increased by 64%. Concomitantly the cell volume has increased by 53%.

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