RENAL TUBULAR CELL NECROSIS AND APOPTOSIS IN TRANSPLANTED KIDNEYS

Authors

  • E. Toronyi,

    1. Department of Transplantation and General Surgery, Semmelweis University, H-1082, Budapest, Baross u. 23–25, Hungary
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  • R. Lord,

    1. University Hospital of Cardiff University, Wales, Cardiff, CF1 3TL, UK
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  • I. D. Bowen,

    1. School of Biosciences, Cardiff University, PO Box 915, Cardiff, CF1 3TL, UK
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  • F. Perner,

    1. Department of Transplantation and General Surgery, Semmelweis University, H-1082, Budapest, Baross u. 23–25, Hungary
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  • Dr B. Szende

    Corresponding author
    1. I. Institute of Pathology and Experimental Cancer Research, Research Group of Molecular Pathology of the Joint Research Organisation of the Semmelweis University and the Hungarian Academy of Sciences, H-1085, Budapest, Üllöi ut 26, Hungary
      1st Institute of Pathology and Experimental Cancer Research, Semmelweis University, H-1085 Budapest, Üllöi út 26., Hungary. E-mail: bszende@korb1.sote.hu
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1st Institute of Pathology and Experimental Cancer Research, Semmelweis University, H-1085 Budapest, Üllöi út 26., Hungary. E-mail: bszende@korb1.sote.hu

Abstract

Renal wedge biopsies were taken from donors' kidneys immediately at the end of cold ischaemia and 30min after transplantation in 11 cases. Five renal grafts showed immediate and six showed delayed renal function clinically. The ratio of apoptotic and necrotic renal tubular cells and Ki67 activity was determined in both biopsies. Necrotic and apoptotic as well as proliferating renal tubular cells were seen in all samples. Both apoptotic and proliferative activity was decreased in samples taken 30min after transplantation in cases of immediate renal function compared to the samples taken before transplantation. This phenomenon was not observed in cases of delayed renal function.

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