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INHIBITION OF THE CONTRACTION OF COLLAGEN GELS BY EXTRACTS FROM HUMAN DERMIS
Article first published online: 2 JAN 2013
© The Author(s) Journal compilation © 2001 International Federation for Cell Biology
Cell Biology International
Volume 25, Issue 7, pages 635–642, July 2001
How to Cite
El-Sheemy, M. A., Muir, I. F. K., Wheatley, D. N. and Eremin, O. (2001), INHIBITION OF THE CONTRACTION OF COLLAGEN GELS BY EXTRACTS FROM HUMAN DERMIS. Cell Biology International, 25: 635–642. doi: 10.1006/cbir.2000.0694
- Issue published online: 2 JAN 2013
- Article first published online: 2 JAN 2013
- Accepted 26 October 2000; Received 3 March 2000
- Cited By
- DSPG II;
- collagen gels;
- wound healing
Extracts from the human dermis were prepared and evaluated with respect to their ability to influence fibroblasts to contract collagen gels in vitro. The extract which had the most inhibitory effect on fibroblasts to cause contraction of collagen gels was extract D. It also inhibited fibroblast growth. Inhibition of contraction was not simply related to fibroblast cell numbers and the data suggests a specific effect upon the ability of fibroblasts to cause contraction. Other extracts were without significant effect.